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- W4207032181 abstract "Intraflagellar transport (IFT) carries proteins into flagella but how IFT trains interact with the large number of diverse proteins required to assemble flagella remains largely unknown. Here, we show that IFT of radial spokes in Chlamydomonas requires ARMC2/PF27, a conserved armadillo repeat protein associated with male infertility and reduced lung function. Chlamydomonas ARMC2 was highly enriched in growing flagella and tagged ARMC2 and the spoke protein RSP3 co-migrated on anterograde trains. In contrast, a cargo and an adapter of inner and outer dynein arms moved independently of ARMC2, indicating that unrelated cargoes distribute stochastically onto the IFT trains. After concomitant unloading at the flagellar tip, RSP3 attached to the axoneme whereas ARMC2 diffused back to the cell body. In armc2/pf27 mutants, IFT of radial spokes was abolished and the presence of radial spokes was limited to the proximal region of flagella. We conclude that ARMC2 is a cargo adapter required for IFT of radial spokes to ensure their assembly along flagella. ARMC2 belongs to a growing class of cargo-specific adapters that enable flagellar transport of preassembled axonemal substructures by IFT." @default.
- W4207032181 created "2022-01-26" @default.
- W4207032181 creator A5003411214 @default.
- W4207032181 creator A5045663809 @default.
- W4207032181 creator A5050955630 @default.
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- W4207032181 creator A5071028767 @default.
- W4207032181 creator A5071313331 @default.
- W4207032181 creator A5089541729 @default.
- W4207032181 date "2022-01-04" @default.
- W4207032181 modified "2023-10-01" @default.
- W4207032181 title "Chlamydomonas ARMC2/PF27 is an obligate cargo adapter for intraflagellar transport of radial spokes" @default.
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