FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207034013> ?p ?o ?g. }

• W4207034013 endingPage "275" @default.
• W4207034013 startingPage "257" @default.
• W4207034013 abstract "Uncovering mechanisms of acquired drug resistance has garnered increasing attention worldwide as drug resistance reduces antibiotic and chemotherapy effectiveness. Most bioinformatics studies have elucidated these mechanisms based on differentially expressed gene (DEG) analysis. However, considering the associated complex network of biological systems, the specific molecular interactions must also be studied to obtain a complete understanding of the mechanisms related to drug resistance. Accordingly, by analyzing sample-specific gene networks, we sought to elucidate mechanisms of acquired drug resistance of cells based on molecular interactions between genes. In the current study, we focus on gefitinib and erlotinib and characterized cell lines based on their sensitivity. We also consider CRISPR knockout screening of the target gene, epidermal growth factor receptor (EGFR), as a characteristic of cells. Subsequently, we constructed a drug sensitivity-CRISPR knockout screen-specific gene network. To identify the molecular mechanisms of drug resistance from the multiple large-scale networks, we proposed a novel computational method, designated network-constrained sparse common component analysis (NetSCCA), that extracts common structures of multiple networks characterizing molecular interaction in drug-sensitive and drug-resistant cell lines. We then applied NetSCCA to multilayer networks of candidate drug-response genes to identify common structures of the regulatory system in drug-sensitive and EGFR-dependent cells, and drug-resistant and EGFR-independent cells. NetSCCA identified crucial common targets and regulator genes that dominate multiple networks in drug-sensitive and drug-resistant cell lines, respectively. Our analysis for common structure identification based on NetSCCA has the capacity to characterize the molecular interplay between genes and crucial markers related to mechanisms of acquired drug resistance that cannot be revealed by analysis based solely on DEG analysis. The biological mechanisms associated with gefitinib and erlotinib sensitivity of identified genes were verified through the literature. We expect that the proposed method will serve as a useful tool for uncovering not only drug resistance mechanisms but also complex biological systems based on massive genomic data sets." @default.
• W4207034013 created "2022-01-26" @default.
• W4207034013 creator A5078146127 @default.
• W4207034013 creator A5083045655 @default.
• W4207034013 creator A5088167618 @default.
• W4207034013 creator A5090788230 @default.
• W4207034013 date "2022-03-01" @default.
• W4207034013 modified "2023-10-17" @default.
• W4207034013 title "Uncovering Molecular Mechanisms of Drug Resistance via Network-Constrained Common Structure Identification" @default.
• W4207034013 cites W1845409317 @default.
• W4207034013 cites W1970439470 @default.
• W4207034013 cites W1975900269 @default.
• W4207034013 cites W1983774108 @default.
• W4207034013 cites W1985928174 @default.
• W4207034013 cites W1997307068 @default.
• W4207034013 cites W2000050049 @default.
• W4207034013 cites W2005461786 @default.
• W4207034013 cites W2008075361 @default.
• W4207034013 cites W2018360198 @default.
• W4207034013 cites W2033825058 @default.
• W4207034013 cites W2053680453 @default.
• W4207034013 cites W2058736322 @default.
• W4207034013 cites W2080610970 @default.
• W4207034013 cites W2081275125 @default.
• W4207034013 cites W2098290597 @default.
• W4207034013 cites W2101017424 @default.
• W4207034013 cites W2101220375 @default.
• W4207034013 cites W2122825543 @default.
• W4207034013 cites W2139129884 @default.
• W4207034013 cites W2141037581 @default.
• W4207034013 cites W2142436130 @default.
• W4207034013 cites W2153011302 @default.
• W4207034013 cites W2161409973 @default.
• W4207034013 cites W2165009258 @default.
• W4207034013 cites W2166245471 @default.
• W4207034013 cites W2197806847 @default.
• W4207034013 cites W2302358198 @default.
• W4207034013 cites W2316777574 @default.
• W4207034013 cites W2566835380 @default.
• W4207034013 cites W2598217298 @default.
• W4207034013 cites W2616721380 @default.
• W4207034013 cites W2766913095 @default.
• W4207034013 cites W2767731705 @default.
• W4207034013 cites W2793920028 @default.
• W4207034013 cites W2808346532 @default.
• W4207034013 cites W2809205245 @default.
• W4207034013 cites W2810691578 @default.
• W4207034013 cites W2890684196 @default.
• W4207034013 cites W2904440587 @default.
• W4207034013 cites W2922365660 @default.
• W4207034013 cites W2942593273 @default.
• W4207034013 cites W3010707783 @default.
• W4207034013 cites W3087828383 @default.
• W4207034013 cites W3140661690 @default.
• W4207034013 doi "https://doi.org/10.1089/cmb.2021.0314" @default.
• W4207034013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35073162" @default.
• W4207034013 hasPublicationYear "2022" @default.
• W4207034013 type Work @default.
• W4207034013 citedByCount "1" @default.
• W4207034013 countsByYear W42070340132022 @default.
• W4207034013 crossrefType "journal-article" @default.
• W4207034013 hasAuthorship W4207034013A5078146127 @default.
• W4207034013 hasAuthorship W4207034013A5083045655 @default.
• W4207034013 hasAuthorship W4207034013A5088167618 @default.
• W4207034013 hasAuthorship W4207034013A5090788230 @default.
• W4207034013 hasConcept C104317684 @default.
• W4207034013 hasConcept C114851261 @default.
• W4207034013 hasConcept C150194340 @default.
• W4207034013 hasConcept C152662350 @default.
• W4207034013 hasConcept C170493617 @default.
• W4207034013 hasConcept C2778087573 @default.
• W4207034013 hasConcept C2779438470 @default.
• W4207034013 hasConcept C2780035454 @default.
• W4207034013 hasConcept C2780580887 @default.
• W4207034013 hasConcept C28225019 @default.
• W4207034013 hasConcept C54355233 @default.
• W4207034013 hasConcept C60644358 @default.
• W4207034013 hasConcept C67339327 @default.
• W4207034013 hasConcept C70721500 @default.
• W4207034013 hasConcept C74187038 @default.
• W4207034013 hasConcept C86803240 @default.
• W4207034013 hasConcept C98274493 @default.
• W4207034013 hasConceptScore W4207034013C104317684 @default.
• W4207034013 hasConceptScore W4207034013C114851261 @default.
• W4207034013 hasConceptScore W4207034013C150194340 @default.
• W4207034013 hasConceptScore W4207034013C152662350 @default.
• W4207034013 hasConceptScore W4207034013C170493617 @default.
• W4207034013 hasConceptScore W4207034013C2778087573 @default.
• W4207034013 hasConceptScore W4207034013C2779438470 @default.
• W4207034013 hasConceptScore W4207034013C2780035454 @default.
• W4207034013 hasConceptScore W4207034013C2780580887 @default.
• W4207034013 hasConceptScore W4207034013C28225019 @default.
• W4207034013 hasConceptScore W4207034013C54355233 @default.
• W4207034013 hasConceptScore W4207034013C60644358 @default.
• W4207034013 hasConceptScore W4207034013C67339327 @default.
• W4207034013 hasConceptScore W4207034013C70721500 @default.
• W4207034013 hasConceptScore W4207034013C74187038 @default.
• W4207034013 hasConceptScore W4207034013C86803240 @default.

• next