FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207035352> ?p ?o ?g. }

• W4207035352 endingPage "1961" @default.
• W4207035352 startingPage "1952" @default.
• W4207035352 abstract "The approximation of euglycemia is the most effective means of preventing diabetic complications, which is achieved through effective insulin delivery. Recent reports indicate that insulin phenolic preservatives, which are found in all commercial insulin formulations, are cytotoxic, pro-inflammatory and induce secondary fibrosis. Therefore, we hypothesize that these preservatives induce an inflammatory response at the site of insulin infusion leading to diminished glycemic control and adverse pharmacokinetic outcomes. Insulin degradation by inflammatory cell proteases was quantitated following protease treatment in vitro. A modified murine air pouch model was utilized to evaluate the relative inflammatory responses following infusions of saline, insulin preservatives, and insulin, utilizing the adjuvant irritant thioglycolate. Blood glucose levels were monitored in diabetic mice with and without air pouch irritation. A pharmacokinetic analysis evaluated insulin effectiveness for diabetic mice between these two conditions. Inflammatory cells are significantly present in insulin preservative-induced inflammation, which effects diminished blood glucose control by both insulin uptake and degradation. Insulin containing these preservatives resulted in similar degrees of inflammation as observed with the irritant thioglycolate. These studies imply that the preservative agents found in commercial insulin formulations induce an intense localized inflammatory reaction. This inflammatory reaction may be responsible for the premature failure of insulin infusion devices. Future studies directed at reducing this inflammatory reaction may prove to be an important step in extending the lifespan of insulin infusion devices." @default.
• W4207035352 created "2022-01-26" @default.
• W4207035352 creator A5008719797 @default.
• W4207035352 creator A5012480729 @default.
• W4207035352 creator A5019891745 @default.
• W4207035352 creator A5023135321 @default.
• W4207035352 creator A5059538288 @default.
• W4207035352 creator A5083643096 @default.
• W4207035352 creator A5087881382 @default.
• W4207035352 date "2022-07-01" @default.
• W4207035352 modified "2023-10-14" @default.
• W4207035352 title "Inflammation at Site of Insulin Infusion Diminishes Glycemic Control" @default.
• W4207035352 cites W1551337262 @default.
• W4207035352 cites W1562321590 @default.
• W4207035352 cites W1565468145 @default.
• W4207035352 cites W1849011750 @default.
• W4207035352 cites W1861980580 @default.
• W4207035352 cites W1953961304 @default.
• W4207035352 cites W1966562602 @default.
• W4207035352 cites W196767433 @default.
• W4207035352 cites W1972348237 @default.
• W4207035352 cites W1981164033 @default.
• W4207035352 cites W2001685706 @default.
• W4207035352 cites W2010815829 @default.
• W4207035352 cites W2016285437 @default.
• W4207035352 cites W2019227795 @default.
• W4207035352 cites W2020305610 @default.
• W4207035352 cites W2026697237 @default.
• W4207035352 cites W2027737492 @default.
• W4207035352 cites W2033683019 @default.
• W4207035352 cites W2039905894 @default.
• W4207035352 cites W2043276602 @default.
• W4207035352 cites W2045262199 @default.
• W4207035352 cites W2049929227 @default.
• W4207035352 cites W2052900362 @default.
• W4207035352 cites W2062042301 @default.
• W4207035352 cites W2064870135 @default.
• W4207035352 cites W2084007851 @default.
• W4207035352 cites W2094458427 @default.
• W4207035352 cites W2098570086 @default.
• W4207035352 cites W2133898930 @default.
• W4207035352 cites W2139378297 @default.
• W4207035352 cites W2145249616 @default.
• W4207035352 cites W2157940881 @default.
• W4207035352 cites W2165248259 @default.
• W4207035352 cites W2396062407 @default.
• W4207035352 cites W2562554519 @default.
• W4207035352 cites W2784126038 @default.
• W4207035352 cites W284565234 @default.
• W4207035352 cites W2891649134 @default.
• W4207035352 cites W2909166675 @default.
• W4207035352 cites W2924672833 @default.
• W4207035352 cites W2938305702 @default.
• W4207035352 cites W2947157643 @default.
• W4207035352 cites W2954450465 @default.
• W4207035352 cites W2998540783 @default.
• W4207035352 cites W3008101813 @default.
• W4207035352 cites W3009349925 @default.
• W4207035352 cites W3083875229 @default.
• W4207035352 cites W3162026208 @default.
• W4207035352 cites W3177445960 @default.
• W4207035352 cites W3184563503 @default.
• W4207035352 cites W3201472683 @default.
• W4207035352 cites W347287407 @default.
• W4207035352 cites W39672263 @default.
• W4207035352 cites W4211006098 @default.
• W4207035352 cites W72683758 @default.
• W4207035352 doi "https://doi.org/10.1016/j.xphs.2021.12.025" @default.
• W4207035352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34986358" @default.
• W4207035352 hasPublicationYear "2022" @default.
• W4207035352 type Work @default.
• W4207035352 citedByCount "4" @default.
• W4207035352 countsByYear W42070353522023 @default.
• W4207035352 crossrefType "journal-article" @default.
• W4207035352 hasAuthorship W4207035352A5008719797 @default.
• W4207035352 hasAuthorship W4207035352A5012480729 @default.
• W4207035352 hasAuthorship W4207035352A5019891745 @default.
• W4207035352 hasAuthorship W4207035352A5023135321 @default.
• W4207035352 hasAuthorship W4207035352A5059538288 @default.
• W4207035352 hasAuthorship W4207035352A5083643096 @default.
• W4207035352 hasAuthorship W4207035352A5087881382 @default.
• W4207035352 hasBestOaLocation W42070353522 @default.
• W4207035352 hasConcept C126322002 @default.
• W4207035352 hasConcept C2776914184 @default.
• W4207035352 hasConcept C2779306644 @default.
• W4207035352 hasConcept C2780473172 @default.
• W4207035352 hasConcept C71924100 @default.
• W4207035352 hasConcept C98274493 @default.
• W4207035352 hasConceptScore W4207035352C126322002 @default.
• W4207035352 hasConceptScore W4207035352C2776914184 @default.
• W4207035352 hasConceptScore W4207035352C2779306644 @default.
• W4207035352 hasConceptScore W4207035352C2780473172 @default.
• W4207035352 hasConceptScore W4207035352C71924100 @default.
• W4207035352 hasConceptScore W4207035352C98274493 @default.
• W4207035352 hasIssue "7" @default.
• W4207035352 hasLocation W42070353521 @default.
• W4207035352 hasLocation W42070353522 @default.
• W4207035352 hasLocation W42070353523 @default.

• next