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- W4207035694 startingPage "134820" @default.
- W4207035694 abstract "Malignant osteosarcoma is one of the serious health concerns attributed to inferior prognosis and uncontrolled metastasis in clinics. Indeed, multifunctional therapeutics with precise tumor killing and subsequent regeneration of damaged tissue are of immense requirement in treating osteosarcoma. Herein, this study demonstrates the fabrication of versatile calcium/copper-impregnated bioactive glass (Ca-BG/Cu-BG) frameworks with orchestrated cancer inhibition and bone tissue calcification towards osteosarcoma therapy. Initially, the designed composites are systematically characterized to explore various morphological attributes and physicochemical properties. The optimal formulation of Cu-BG (10 mol%) presented orchestrated effects of an excellent pH-responsive anticancer effect through hydroxyl radical (·OH) generation and facilitated hydroxyapatite formation towards bone tissue calcification. Further, in vitro investigations demonstrated substantial biocompatibility in mouse embryo osteoblast precursor cell line (MC3T3-E1) and exceptional anti-tumor effects in human osteosarcoma cells (HOS) through improved cellular internalization efficacy and free radical generation, respectively. Finally, in vivo immunostaining and micro-computed tomography (μCT) images of osteosarcoma-bearing mice confirmed Fenton-like reaction-induced chemodynamic therapy (CDT), over-expressed hypoxia-inducible factor (HIF)-1α through p53 pathway, and formation of calcified nodules. In addition, hematological analyses of hematoxylin-eosin (HE) stained main organ sections presented biosafety elucidations. Together, the synergistic prospects of Cu2+ and Ca2+ species had substantially orchestrated towards regenerative medicine." @default.
- W4207035694 created "2022-01-26" @default.
- W4207035694 creator A5011423173 @default.
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- W4207035694 date "2022-05-01" @default.
- W4207035694 modified "2023-10-17" @default.
- W4207035694 title "Orchestrated tumor apoptosis (Cu2+) and bone tissue calcification (Ca2+) by hierarchical Copper/Calcium-ensembled bioactive silica for osteosarcoma therapy" @default.
- W4207035694 cites W1607531254 @default.
- W4207035694 cites W1982414211 @default.
- W4207035694 cites W2030602664 @default.
- W4207035694 cites W2051926344 @default.
- W4207035694 cites W2067855632 @default.
- W4207035694 cites W2072253461 @default.
- W4207035694 cites W2074480129 @default.
- W4207035694 cites W2078690041 @default.
- W4207035694 cites W2080944862 @default.
- W4207035694 cites W2112238783 @default.
- W4207035694 cites W2151420872 @default.
- W4207035694 cites W2162118093 @default.
- W4207035694 cites W2283244606 @default.
- W4207035694 cites W2557072953 @default.
- W4207035694 cites W2559777051 @default.
- W4207035694 cites W2578623881 @default.
- W4207035694 cites W2581453412 @default.
- W4207035694 cites W2594111041 @default.
- W4207035694 cites W2606969462 @default.
- W4207035694 cites W2727722511 @default.
- W4207035694 cites W2759043931 @default.
- W4207035694 cites W2760827518 @default.
- W4207035694 cites W2767211143 @default.
- W4207035694 cites W2775185528 @default.
- W4207035694 cites W2789262370 @default.
- W4207035694 cites W2790553322 @default.
- W4207035694 cites W2792154012 @default.
- W4207035694 cites W2793503277 @default.
- W4207035694 cites W2801096691 @default.
- W4207035694 cites W2883440571 @default.
- W4207035694 cites W2897572687 @default.
- W4207035694 cites W2899865898 @default.
- W4207035694 cites W2900313041 @default.
- W4207035694 cites W2903659409 @default.
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- W4207035694 cites W2926367219 @default.
- W4207035694 cites W2929435855 @default.
- W4207035694 cites W2930441154 @default.
- W4207035694 cites W2931433494 @default.
- W4207035694 cites W2939714203 @default.
- W4207035694 cites W2954904043 @default.
- W4207035694 cites W2958472393 @default.
- W4207035694 cites W2962262661 @default.
- W4207035694 cites W2968798941 @default.
- W4207035694 cites W2972875264 @default.
- W4207035694 cites W2979402130 @default.
- W4207035694 cites W2982280565 @default.
- W4207035694 cites W2986546735 @default.
- W4207035694 cites W2994439439 @default.
- W4207035694 cites W2994964009 @default.
- W4207035694 cites W3002166990 @default.
- W4207035694 cites W3004640299 @default.
- W4207035694 cites W3009139928 @default.
- W4207035694 cites W3012497599 @default.
- W4207035694 cites W3014391213 @default.
- W4207035694 cites W3016733806 @default.
- W4207035694 cites W3023715334 @default.
- W4207035694 cites W3024111459 @default.
- W4207035694 cites W3048341438 @default.
- W4207035694 cites W3049464151 @default.
- W4207035694 cites W3081387755 @default.
- W4207035694 cites W3087605059 @default.
- W4207035694 cites W3092346227 @default.
- W4207035694 cites W3106639186 @default.
- W4207035694 cites W3110998212 @default.
- W4207035694 cites W3116369578 @default.
- W4207035694 cites W3119658360 @default.
- W4207035694 cites W3125724405 @default.
- W4207035694 cites W3125944921 @default.
- W4207035694 cites W3129581908 @default.
- W4207035694 cites W3131034435 @default.
- W4207035694 cites W3132055085 @default.
- W4207035694 cites W3135372736 @default.
- W4207035694 cites W3155870764 @default.
- W4207035694 cites W3177987191 @default.
- W4207035694 cites W3195702463 @default.
- W4207035694 cites W3204490709 @default.
- W4207035694 cites W4210298392 @default.
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- W4207035694 doi "https://doi.org/10.1016/j.cej.2022.134820" @default.
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