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- W4207036166 abstract "Cellular signaling mechanisms are designed to transmit information from the cell surface to specific targets within the cell. The generation of a concentration gradient of unique intracellular messengers is a universal strategy to convert extracellular stimuli in an intracellular response. Among the intracellular messengers, calcium ion (Ca 2+ ) is one of the most important and it is ubiquitously utilized by essentially all the living organisms. A transient increase in the cytosolic Ca 2+ concentration, [Ca 2+ ] c , is commonly used by the cell to activate many different cellular functions. The specificity of the signal is guaranteed by the complex spatial and temporal organization of the changes in Ca 2+ concentration, which increases the versatility of this messenger. Furthermore, the existence of different calcium sensing proteins is in place to properly interpret the Ca 2+ signal and enable different cell types to use it as appropriate to their physiology. The ability to use Ca 2+ in different modes helps cells to vary the amplitude, frequency, kinetics, and localization of the signal. It is now recognized that periodic [Ca 2+ ] c changes (i.e., oscillations) represent a typical response of cells to physiological agonists concentrations and that the activation of the biological response occurs upon the integration of the oscillatory signal." @default.
- W4207036166 created "2022-01-26" @default.
- W4207036166 creator A5015986695 @default.
- W4207036166 date "2021-01-01" @default.
- W4207036166 modified "2023-09-25" @default.
- W4207036166 title "Calcium | Calcium Oscillations" @default.
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- W4207036166 doi "https://doi.org/10.1016/b978-0-12-819460-7.00315-7" @default.
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