Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207037385> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4207037385 abstract "Abstract Background: To develop and evaluate the prognostic value of a comprehensive inflammatory biomarker for postoperative colorectal cancer (CRC) patients. Methods: A total of 646 CRC patients were recruited between August 2017 and December 2019 from Fujian Medical University Union Hospital, with follow-up data up to 2021. The least absolute shrinkage and selection operator method (LASSO) was used to select inflammation indicators in order to construct a comprehensive biomarker (named NSAP). The Cox regression model was utilized to analyze the association between the NSAP and the disease-free survival (DFS) of CRC. Predictive performance and clinical utility of prognostic models were evaluated by area under the curve (AUC) and decision curve analyses (DCAs). Results: During a median follow-up of 23 months, 95 clinical outcomes were observed, with a one-year survival rate is 89.47%. A comprehensive inflammatory biomarker (NSAP) was established based on four blood indicators (including Neutrophil-to-Lymphocyte Ratio (NLR), Neutrophil×Monocyte-to-Lymphocyte Ratio (SIRI), Albumin-to-Globulin Ratio (AGR) and Platelet-to-Lymphocytes Ratio (PLR)). Patients with a lower NSAP had significantly associated with better DFS of CRC (HR=0.53, 95%CI: 0.32-0.89). Moreover, compared to a previously established model, the traditional TNM staging system or/and tumor markers, the nomogram based on NSAP displayed more excellent predictive ability (0.752 vs 0.597, 0.711 and 0.735, P < 0.05). DCAs also demonstrated that the established nomogram had better utility for decision making. Conclusions: Our study suggests that NSAP may be a useful comprehensive prognostic biomarker for predicting the DFS of CRC patients. The nomogram based on NSAP can be considered a valuable tool to estimate the prognosis of patients with CRC." @default.
- W4207037385 created "2022-01-26" @default.
- W4207037385 creator A5015042905 @default.
- W4207037385 creator A5039412958 @default.
- W4207037385 creator A5046378290 @default.
- W4207037385 creator A5046454314 @default.
- W4207037385 creator A5048848316 @default.
- W4207037385 creator A5054266274 @default.
- W4207037385 creator A5056623428 @default.
- W4207037385 creator A5058451656 @default.
- W4207037385 creator A5064719606 @default.
- W4207037385 creator A5082964883 @default.
- W4207037385 date "2022-01-24" @default.
- W4207037385 modified "2023-09-26" @default.
- W4207037385 title "A Novel Inflammation-Related Prognostic Biomarker for Predicting The Disease-free Survival of Patients With Colorectal Cancer" @default.
- W4207037385 doi "https://doi.org/10.21203/rs.3.rs-1268811/v1" @default.
- W4207037385 hasPublicationYear "2022" @default.
- W4207037385 type Work @default.
- W4207037385 citedByCount "0" @default.
- W4207037385 crossrefType "posted-content" @default.
- W4207037385 hasAuthorship W4207037385A5015042905 @default.
- W4207037385 hasAuthorship W4207037385A5039412958 @default.
- W4207037385 hasAuthorship W4207037385A5046378290 @default.
- W4207037385 hasAuthorship W4207037385A5046454314 @default.
- W4207037385 hasAuthorship W4207037385A5048848316 @default.
- W4207037385 hasAuthorship W4207037385A5054266274 @default.
- W4207037385 hasAuthorship W4207037385A5056623428 @default.
- W4207037385 hasAuthorship W4207037385A5058451656 @default.
- W4207037385 hasAuthorship W4207037385A5064719606 @default.
- W4207037385 hasAuthorship W4207037385A5082964883 @default.
- W4207037385 hasBestOaLocation W42070373851 @default.
- W4207037385 hasConcept C121608353 @default.
- W4207037385 hasConcept C126322002 @default.
- W4207037385 hasConcept C143998085 @default.
- W4207037385 hasConcept C146357865 @default.
- W4207037385 hasConcept C151730666 @default.
- W4207037385 hasConcept C2778963024 @default.
- W4207037385 hasConcept C2781197716 @default.
- W4207037385 hasConcept C3019894029 @default.
- W4207037385 hasConcept C34626388 @default.
- W4207037385 hasConcept C50382708 @default.
- W4207037385 hasConcept C526805850 @default.
- W4207037385 hasConcept C55493867 @default.
- W4207037385 hasConcept C71924100 @default.
- W4207037385 hasConcept C86803240 @default.
- W4207037385 hasConceptScore W4207037385C121608353 @default.
- W4207037385 hasConceptScore W4207037385C126322002 @default.
- W4207037385 hasConceptScore W4207037385C143998085 @default.
- W4207037385 hasConceptScore W4207037385C146357865 @default.
- W4207037385 hasConceptScore W4207037385C151730666 @default.
- W4207037385 hasConceptScore W4207037385C2778963024 @default.
- W4207037385 hasConceptScore W4207037385C2781197716 @default.
- W4207037385 hasConceptScore W4207037385C3019894029 @default.
- W4207037385 hasConceptScore W4207037385C34626388 @default.
- W4207037385 hasConceptScore W4207037385C50382708 @default.
- W4207037385 hasConceptScore W4207037385C526805850 @default.
- W4207037385 hasConceptScore W4207037385C55493867 @default.
- W4207037385 hasConceptScore W4207037385C71924100 @default.
- W4207037385 hasConceptScore W4207037385C86803240 @default.
- W4207037385 hasLocation W42070373851 @default.
- W4207037385 hasLocation W42070373852 @default.
- W4207037385 hasOpenAccess W4207037385 @default.
- W4207037385 hasPrimaryLocation W42070373851 @default.
- W4207037385 hasRelatedWork W12927781 @default.
- W4207037385 hasRelatedWork W14070955 @default.
- W4207037385 hasRelatedWork W14146858 @default.
- W4207037385 hasRelatedWork W14783117 @default.
- W4207037385 hasRelatedWork W18087383 @default.
- W4207037385 hasRelatedWork W19091456 @default.
- W4207037385 hasRelatedWork W2620331 @default.
- W4207037385 hasRelatedWork W6779540 @default.
- W4207037385 hasRelatedWork W7720014 @default.
- W4207037385 hasRelatedWork W6821153 @default.
- W4207037385 isParatext "false" @default.
- W4207037385 isRetracted "false" @default.
- W4207037385 workType "article" @default.