Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207041710> ?p ?o ?g. }
- W4207041710 endingPage "526" @default.
- W4207041710 startingPage "513" @default.
- W4207041710 abstract "Cellular senescence is a stable cell growth arrest. Senescent cells are metabolically active, as exemplified by the secretion of inflammatory cytokines, chemokines, and growth factors, which is termed senescence-associated secretory phenotype (SASP). The SASP exerts a range of functions in both normal health and pathology, which is possibly best characterized in cancers and physical aging. Recent studies demonstrated that chromatin is instrumental in regulating the SASP both through nuclear transcription and via the innate immune cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway in the cytoplasm. Here, we will review these regulatory mechanisms, with an emphasis on most recent developments in the field. We will highlight the challenges and opportunities in developing intervention approaches, such as targeting chromatin regulatory mechanisms, to alter the SASP as an emerging approach to combat cancers and achieve healthy aging." @default.
- W4207041710 created "2022-01-26" @default.
- W4207041710 creator A5013038112 @default.
- W4207041710 creator A5067131328 @default.
- W4207041710 creator A5076541737 @default.
- W4207041710 date "2022-06-01" @default.
- W4207041710 modified "2023-10-06" @default.
- W4207041710 title "Chromatin basis of the senescence-associated secretory phenotype" @default.
- W4207041710 cites W1033197108 @default.
- W4207041710 cites W1647232018 @default.
- W4207041710 cites W1800944583 @default.
- W4207041710 cites W1898081212 @default.
- W4207041710 cites W1910950086 @default.
- W4207041710 cites W1965124005 @default.
- W4207041710 cites W1973062929 @default.
- W4207041710 cites W1976635482 @default.
- W4207041710 cites W1977362098 @default.
- W4207041710 cites W1987198779 @default.
- W4207041710 cites W1992082488 @default.
- W4207041710 cites W2004273407 @default.
- W4207041710 cites W2010417927 @default.
- W4207041710 cites W2026890342 @default.
- W4207041710 cites W2027849227 @default.
- W4207041710 cites W2044341880 @default.
- W4207041710 cites W2047330128 @default.
- W4207041710 cites W2059370490 @default.
- W4207041710 cites W2061765285 @default.
- W4207041710 cites W2064537118 @default.
- W4207041710 cites W2065006553 @default.
- W4207041710 cites W2069519394 @default.
- W4207041710 cites W2070021921 @default.
- W4207041710 cites W2074350232 @default.
- W4207041710 cites W2078281194 @default.
- W4207041710 cites W2087999409 @default.
- W4207041710 cites W2090067193 @default.
- W4207041710 cites W2099610218 @default.
- W4207041710 cites W2104222537 @default.
- W4207041710 cites W2124614845 @default.
- W4207041710 cites W2131078803 @default.
- W4207041710 cites W2132224453 @default.
- W4207041710 cites W2150748567 @default.
- W4207041710 cites W2153643905 @default.
- W4207041710 cites W2154171253 @default.
- W4207041710 cites W2155846733 @default.
- W4207041710 cites W2162229546 @default.
- W4207041710 cites W2193792657 @default.
- W4207041710 cites W2201760124 @default.
- W4207041710 cites W2257877079 @default.
- W4207041710 cites W2262370504 @default.
- W4207041710 cites W2299167488 @default.
- W4207041710 cites W2299946646 @default.
- W4207041710 cites W2342055991 @default.
- W4207041710 cites W2416744721 @default.
- W4207041710 cites W2518194013 @default.
- W4207041710 cites W2520029120 @default.
- W4207041710 cites W2540036007 @default.
- W4207041710 cites W2591766939 @default.
- W4207041710 cites W2597375791 @default.
- W4207041710 cites W2613773167 @default.
- W4207041710 cites W2614144400 @default.
- W4207041710 cites W2618634776 @default.
- W4207041710 cites W2627064270 @default.
- W4207041710 cites W2742007963 @default.
- W4207041710 cites W2748810297 @default.
- W4207041710 cites W2762611634 @default.
- W4207041710 cites W2799540870 @default.
- W4207041710 cites W2804523989 @default.
- W4207041710 cites W2805184558 @default.
- W4207041710 cites W2810612816 @default.
- W4207041710 cites W2842198498 @default.
- W4207041710 cites W2884053119 @default.
- W4207041710 cites W2897749150 @default.
- W4207041710 cites W2898830231 @default.
- W4207041710 cites W2911642321 @default.
- W4207041710 cites W2914025980 @default.
- W4207041710 cites W2921681769 @default.
- W4207041710 cites W2945498322 @default.
- W4207041710 cites W2952829451 @default.
- W4207041710 cites W2960264922 @default.
- W4207041710 cites W2980875709 @default.
- W4207041710 cites W2995325699 @default.
- W4207041710 cites W2995771616 @default.
- W4207041710 cites W2997287435 @default.
- W4207041710 cites W3000364256 @default.
- W4207041710 cites W3004351868 @default.
- W4207041710 cites W3005858280 @default.
- W4207041710 cites W3007472244 @default.
- W4207041710 cites W3013543222 @default.
- W4207041710 cites W3014806409 @default.
- W4207041710 cites W3026751717 @default.
- W4207041710 cites W3028992072 @default.
- W4207041710 cites W3033840227 @default.
- W4207041710 cites W3034793718 @default.
- W4207041710 cites W3082160571 @default.
- W4207041710 cites W3108031567 @default.
- W4207041710 cites W3115516529 @default.
- W4207041710 cites W3127578351 @default.
- W4207041710 cites W3139716940 @default.