FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207043013> ?p ?o ?g. }

• W4207043013 abstract "Although glioblastoma (GB) is associated with a devastating prognosis, a small proportion of patients achieve long-term survival rates. We herein present a matched-pair analysis of molecular factors found in long- and short-term survivors (LTS, STS).We performed a cross-institutional analysis of 262 patient records and matched a group of 91 LTS (≥ 3 years) with two groups of STS (STS-1, n = 91; STS-2, n = 80). Matching was performed according to age, Karnofsky Performance Status, initial therapy and adjuvant therapy. Molecular factors were compared between LTS (total of 91 patients) v. STS-1, and LTS (subgroup of 80 patients) v. STS-2. We included glial fibrillary acidic protein (GFAP), O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation, isocitrate dehydrogenase 1 (IDH-1); furthermore, the proliferation index was analyzed (Ki-67/MIB-1).IDH-1 and decreased Ki-67 were numerically associated with LTS but the difference was only significant compared to STS-1 (n.s. v. STS-2). LTS was associated with MGMT promoter hypermethylation (p = 0.013 and p = 0.022) and GFAP expression (p < 0.001 and p = 0.001). Positivity for both factors combined compared to negativity for one factor occurred more often in the LTS group (p = 0.002 and p = 0.006); negativity for both factors combined did not occur in the LTS group.In this retrospective analysis, GFAP expression and MGMT promoter methylation were associated with LTS. Given the hypothesis-generating nature of our study, these observations should be confirmed in prospective clinical trials." @default.
• W4207043013 created "2022-01-26" @default.
• W4207043013 creator A5005095447 @default.
• W4207043013 creator A5006650814 @default.
• W4207043013 creator A5010375570 @default.
• W4207043013 creator A5021101665 @default.
• W4207043013 creator A5027140083 @default.
• W4207043013 creator A5044074623 @default.
• W4207043013 creator A5049222047 @default.
• W4207043013 creator A5056148870 @default.
• W4207043013 creator A5065034584 @default.
• W4207043013 creator A5074701794 @default.
• W4207043013 creator A5090506665 @default.
• W4207043013 date "2022-01-24" @default.
• W4207043013 modified "2023-10-18" @default.
• W4207043013 title "Molecular features of glioblastomas in long-term survivors compared to short-term survivors—a matched-pair analysis" @default.
• W4207043013 cites W1840228544 @default.
• W4207043013 cites W1970000700 @default.
• W4207043013 cites W1974254625 @default.
• W4207043013 cites W1974689368 @default.
• W4207043013 cites W1977199192 @default.
• W4207043013 cites W1979192765 @default.
• W4207043013 cites W1980295099 @default.
• W4207043013 cites W1996908572 @default.
• W4207043013 cites W2062891123 @default.
• W4207043013 cites W2089944277 @default.
• W4207043013 cites W2096049398 @default.
• W4207043013 cites W2096287682 @default.
• W4207043013 cites W2105100844 @default.
• W4207043013 cites W2129610686 @default.
• W4207043013 cites W2131981377 @default.
• W4207043013 cites W2142016159 @default.
• W4207043013 cites W2148977460 @default.
• W4207043013 cites W2151794458 @default.
• W4207043013 cites W2158681922 @default.
• W4207043013 cites W2163633941 @default.
• W4207043013 cites W2163910135 @default.
• W4207043013 cites W2165871546 @default.
• W4207043013 cites W2168784615 @default.
• W4207043013 cites W2280423797 @default.
• W4207043013 cites W2366536035 @default.
• W4207043013 cites W2529931539 @default.
• W4207043013 cites W2606809940 @default.
• W4207043013 cites W2783471986 @default.
• W4207043013 cites W2913080875 @default.
• W4207043013 cites W3174246647 @default.
• W4207043013 cites W4236116921 @default.
• W4207043013 doi "https://doi.org/10.1186/s13014-022-01984-w" @default.
• W4207043013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35073955" @default.
• W4207043013 hasPublicationYear "2022" @default.
• W4207043013 type Work @default.
• W4207043013 citedByCount "6" @default.
• W4207043013 countsByYear W42070430132022 @default.
• W4207043013 countsByYear W42070430132023 @default.
• W4207043013 crossrefType "journal-article" @default.
• W4207043013 hasAuthorship W4207043013A5005095447 @default.
• W4207043013 hasAuthorship W4207043013A5006650814 @default.
• W4207043013 hasAuthorship W4207043013A5010375570 @default.
• W4207043013 hasAuthorship W4207043013A5021101665 @default.
• W4207043013 hasAuthorship W4207043013A5027140083 @default.
• W4207043013 hasAuthorship W4207043013A5044074623 @default.
• W4207043013 hasAuthorship W4207043013A5049222047 @default.
• W4207043013 hasAuthorship W4207043013A5056148870 @default.
• W4207043013 hasAuthorship W4207043013A5065034584 @default.
• W4207043013 hasAuthorship W4207043013A5074701794 @default.
• W4207043013 hasAuthorship W4207043013A5090506665 @default.
• W4207043013 hasBestOaLocation W42070430131 @default.
• W4207043013 hasConcept C104317684 @default.
• W4207043013 hasConcept C126322002 @default.
• W4207043013 hasConcept C127848430 @default.
• W4207043013 hasConcept C143998085 @default.
• W4207043013 hasConcept C150194340 @default.
• W4207043013 hasConcept C181199279 @default.
• W4207043013 hasConcept C190727270 @default.
• W4207043013 hasConcept C2777150147 @default.
• W4207043013 hasConcept C2779527866 @default.
• W4207043013 hasConcept C33288867 @default.
• W4207043013 hasConcept C501734568 @default.
• W4207043013 hasConcept C54355233 @default.
• W4207043013 hasConcept C552990157 @default.
• W4207043013 hasConcept C55493867 @default.
• W4207043013 hasConcept C71924100 @default.
• W4207043013 hasConcept C86803240 @default.
• W4207043013 hasConcept C91965660 @default.
• W4207043013 hasConceptScore W4207043013C104317684 @default.
• W4207043013 hasConceptScore W4207043013C126322002 @default.
• W4207043013 hasConceptScore W4207043013C127848430 @default.
• W4207043013 hasConceptScore W4207043013C143998085 @default.
• W4207043013 hasConceptScore W4207043013C150194340 @default.
• W4207043013 hasConceptScore W4207043013C181199279 @default.
• W4207043013 hasConceptScore W4207043013C190727270 @default.
• W4207043013 hasConceptScore W4207043013C2777150147 @default.
• W4207043013 hasConceptScore W4207043013C2779527866 @default.
• W4207043013 hasConceptScore W4207043013C33288867 @default.
• W4207043013 hasConceptScore W4207043013C501734568 @default.
• W4207043013 hasConceptScore W4207043013C54355233 @default.
• W4207043013 hasConceptScore W4207043013C552990157 @default.
• W4207043013 hasConceptScore W4207043013C55493867 @default.
• W4207043013 hasConceptScore W4207043013C71924100 @default.
• W4207043013 hasConceptScore W4207043013C86803240 @default.

• next