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- W4207044072 abstract "Myotonic dystrophy type 1 (DM1) is a progressive neuromuscular disease affecting both smooth and striated muscles. It has been suggested that this multisystemic disease also impairs the genitourinary and lower gastrointestinal systems, but information is scattered and no systematic review has been conducted. The objectives of this systematic review were to document (1) symptoms and signs associated with genitourinary and lower gastrointestinal systems in the DM1 population; (2) impacts on quality of life and participation; and (3) efficacy of treatments available to treat those conditions. Among the 75 studies included, 30 articles presented genitourinary outcomes and 67, lower gastrointestinal outcomes. A wide range of symptoms was reported for both systems but most studies were of poor quality, using medical chart reviews without the use of standardized questionnaires. Urinary incontinence, erectile dysfunction, anal incontinence, constipation, diarrhea and abdominal pain were the most described symptoms. Smooth and striated muscle impairment has been documented in small sample size studies. No experimental study evaluated the efficacy of treatments for these conditions. Few descriptive studies described altered quality of life or participation related to these conditions. Further studies should use standardized questionnaires, provide a clear definition of symptoms and investigate treatment options." @default.
- W4207044072 created "2022-01-26" @default.
- W4207044072 creator A5036252454 @default.
- W4207044072 creator A5049948182 @default.
- W4207044072 creator A5059843400 @default.
- W4207044072 creator A5078087146 @default.
- W4207044072 date "2022-05-01" @default.
- W4207044072 modified "2023-10-16" @default.
- W4207044072 title "Genitourinary and lower gastrointestinal conditions in patients with myotonic dystrophy type 1: A systematic review of evidence and implications for clinical practice" @default.
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- W4207044072 doi "https://doi.org/10.1016/j.nmd.2022.01.008" @default.
- W4207044072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35305881" @default.