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• W4207044166 abstract "Compared to most of nano-sized particles, core-shell-structured nanoflowers have received great attention as bioactive materials because of their high surface area with the flower-like structures. In this study, core-shell-structured Si-based NiO nanoflowers, Si@NiO, were prepared by a modified chemical bath deposition method followed by thermal reduction. The crystal morphology and basic structure of the composites were characterized by powder X-ray diffraction (PXRD), Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), specific surface area (BET) and porosity analysis (BJT), and inductively coupled plasma optical emission spectrometry (ICP-OES). The electrochemical properties of the Si@NiO nanoflowers were examined through the redox reaction of ascorbic acid with the metal ions present on the surface of the core-shell nanoflowers. This reaction favored the formation of reactive oxygen species. The Si@NiO nanoflowers showed excellent anticancer activity and low cytotoxicity toward the human breast cancer cell line (MCF-7) and mouse embryonic fibroblasts (MEFs), respectively, demonstrating that the anticancer activities of the Si@NiO nanoflowers were primarily derived from the oxidative capacity of the metal ions on the surface, rather than from the released metal ions. Thus, this proves that Si-based NiO nanoflowers can act as a promising candidate for therapeutic applications." @default.
• W4207044166 created "2022-01-26" @default.
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• W4207044166 date "2022-01-23" @default.
• W4207044166 modified "2023-10-14" @default.
• W4207044166 title "Biocompatible Core–Shell-Structured Si-Based NiO Nanoflowers and Their Anticancer Activity" @default.
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• W4207044166 doi "https://doi.org/10.3390/pharmaceutics14020268" @default.
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