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- W4207044733 endingPage "738" @default.
- W4207044733 startingPage "738" @default.
- W4207044733 abstract "Like other organs, brain functions diminish with age. Furthermore, for a variety of neurological disorders-including Alzheimer's disease-age is one of the higher-risk factors. Since in many Western countries the average age is increasing, determining approaches for decreasing the effects of aging on brain function is taking on a new urgency. Neuroinflammation and oxidative stress are two convoluted key factors in brain aging and chronic neurodegenerative diseases. The diverseness of factors, causing an age-related decrease in brain functions, requires identifying small molecules that have multiple biological activities that can affect all these factors. One great source of these small molecules is related to polyphenolic flavonoids. Recently, 3,3',4',7-tetrahydroxyflavone (fisetin) has been reported as a potent senotherapeutic capable of extending lifespan by reducing peroxidation levels and enhancing antioxidant cell responses. The neuroprotective effects of fisetin have been shown in several in vitro and in vivo models of neurological disorders due to its actions on multiple pathways associated with different neurological disorders. The present work aims to collect the most recent achievements related to the antioxidant and neuroprotective effects of fisetin. Moreover, in silico pharmacokinetics, pharmacodynamics, and toxicity of fisetin are also comprehensively described along with emerging novel drug delivery strategies for the amelioration of this flavonol bioavailability and chemical stability." @default.
- W4207044733 created "2022-01-26" @default.
- W4207044733 creator A5011478837 @default.
- W4207044733 creator A5011913930 @default.
- W4207044733 creator A5055796767 @default.
- W4207044733 creator A5068255593 @default.
- W4207044733 creator A5073062718 @default.
- W4207044733 creator A5089483977 @default.
- W4207044733 date "2022-01-23" @default.
- W4207044733 modified "2023-10-14" @default.
- W4207044733 title "Fisetin as a Senotherapeutic Agent: Biopharmaceutical Properties and Crosstalk between Cell Senescence and Neuroprotection" @default.
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