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• W4207045404 abstract "Palmitic acid (PA) is a saturated free fatty acid which, when being excessive, accounts for lipotoxicity. Using human lung A549 cells as a model for lung alveolar type 2 epithelial cells, we found that challenge of A549 cells with PA resulted in apoptotic cell death, as reflected by positive annexin V and PI staining, and also appearance of cleaved caspase-3. PA treatment also caused depletion of intracellular Ca2+ store, endoplasmic reticulum (ER) stress, and oxidative stress. Tannic acid (TA), a polyphenol present in wines and many beverages, alleviated PA-induced ER stress, oxidative stress and apoptotic death. Thus, our results suggest PA lipotoxicity in lung alveolar type 2 epithelial cells could be protected by TA." @default.
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• W4207045404 date "2021-01-01" @default.
• W4207045404 modified "2023-10-01" @default.
• W4207045404 title "Lipotoxicity in human lung alveolar type 2 A549 cells: Mechanisms and protection by tannic acid" @default.
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• W4207045404 doi "https://doi.org/10.4103/cjp.cjp_68_21" @default.
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