Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207045440> ?p ?o ?g. }
- W4207045440 abstract "Reactive oxygen species production by innate immune cells plays a central role in host defense against invading pathogens at wound-site. A weakened host-defense results in persistent infection leading to wound chronicity. Fermented Papaya Preparation (FPP), a complex sugar matrix, bolsters respiratory burst activity and improves wound healing outcomes in chronic wound patients. The objective of the current study was to identify underlying molecular factor/s responsible for augmenting macrophage host defense mechanisms following FPP supplementation.In depth LC-MS/MS analysis of cells supplemented with FPP led to identification of myo-inositol as a key determinant of FPP activity towards improving macrophage function. Myo-inositol, in quantities that is present in FPP, significantly improved macrophage respiratory burst and phagocytosis via de novo synthesis pathway of ISYNA1. In addition, myo-inositol transporters, HMIT and SMIT1, played a significant role in such activity. Blocking these pathways using siRNA attenuated FPP-induced improved macrophage host defense activities. FPP supplementation emerged as a novel approach to increase intracellular myo-inositol levels. Such supplementation also modified wound microenvironment in chronic wound patients to augment myo-inositol levels in wound fluid.These observations indicate that myo-inositol in FPP influences multiple aspects of macrophage function critical for host defense against invading pathogens." @default.
- W4207045440 created "2022-01-26" @default.
- W4207045440 creator A5001633820 @default.
- W4207045440 creator A5020018621 @default.
- W4207045440 creator A5025713070 @default.
- W4207045440 creator A5029107258 @default.
- W4207045440 creator A5036240909 @default.
- W4207045440 creator A5041570904 @default.
- W4207045440 creator A5056267400 @default.
- W4207045440 creator A5068286486 @default.
- W4207045440 date "2022-02-26" @default.
- W4207045440 modified "2023-10-16" @default.
- W4207045440 title "MYO ‐Inositol In Fermented Sugar Matrix Improves Human Macrophage Function" @default.
- W4207045440 cites W1420654867 @default.
- W4207045440 cites W1492054356 @default.
- W4207045440 cites W1535974848 @default.
- W4207045440 cites W1552654146 @default.
- W4207045440 cites W1568192877 @default.
- W4207045440 cites W1586099293 @default.
- W4207045440 cites W1602389953 @default.
- W4207045440 cites W181123794 @default.
- W4207045440 cites W1881232581 @default.
- W4207045440 cites W1906039037 @default.
- W4207045440 cites W1966677529 @default.
- W4207045440 cites W1968443660 @default.
- W4207045440 cites W1968493125 @default.
- W4207045440 cites W1976072516 @default.
- W4207045440 cites W1977274364 @default.
- W4207045440 cites W1985603803 @default.
- W4207045440 cites W1986415117 @default.
- W4207045440 cites W1986478765 @default.
- W4207045440 cites W1987816826 @default.
- W4207045440 cites W1994473838 @default.
- W4207045440 cites W1994602325 @default.
- W4207045440 cites W1996097380 @default.
- W4207045440 cites W1997093700 @default.
- W4207045440 cites W2001063404 @default.
- W4207045440 cites W2010630254 @default.
- W4207045440 cites W2015750492 @default.
- W4207045440 cites W2039507615 @default.
- W4207045440 cites W2051878772 @default.
- W4207045440 cites W2056064788 @default.
- W4207045440 cites W2056914993 @default.
- W4207045440 cites W2058107898 @default.
- W4207045440 cites W2059668888 @default.
- W4207045440 cites W2075177277 @default.
- W4207045440 cites W2075238900 @default.
- W4207045440 cites W2075869467 @default.
- W4207045440 cites W2079781542 @default.
- W4207045440 cites W2081592239 @default.
- W4207045440 cites W2084897840 @default.
- W4207045440 cites W2085578540 @default.
- W4207045440 cites W2085649042 @default.
- W4207045440 cites W2087358641 @default.
- W4207045440 cites W2090848337 @default.
- W4207045440 cites W2095300435 @default.
- W4207045440 cites W2096407919 @default.
- W4207045440 cites W2097460823 @default.
- W4207045440 cites W2100836696 @default.
- W4207045440 cites W2101190611 @default.
- W4207045440 cites W2112867313 @default.
- W4207045440 cites W2125652903 @default.
- W4207045440 cites W2126788666 @default.
- W4207045440 cites W2127845947 @default.
- W4207045440 cites W2128688376 @default.
- W4207045440 cites W2135328187 @default.
- W4207045440 cites W2135966626 @default.
- W4207045440 cites W2137898985 @default.
- W4207045440 cites W2142866930 @default.
- W4207045440 cites W2147290992 @default.
- W4207045440 cites W2147559640 @default.
- W4207045440 cites W2150861334 @default.
- W4207045440 cites W2156580507 @default.
- W4207045440 cites W2160889581 @default.
- W4207045440 cites W2167872299 @default.
- W4207045440 cites W2167969606 @default.
- W4207045440 cites W2171937401 @default.
- W4207045440 cites W2258135804 @default.
- W4207045440 cites W2277007237 @default.
- W4207045440 cites W2310097628 @default.
- W4207045440 cites W2332378361 @default.
- W4207045440 cites W2397022935 @default.
- W4207045440 cites W2403287989 @default.
- W4207045440 cites W2408516529 @default.
- W4207045440 cites W2421509576 @default.
- W4207045440 cites W2473764235 @default.
- W4207045440 cites W2501013323 @default.
- W4207045440 cites W2516811335 @default.
- W4207045440 cites W2554677618 @default.
- W4207045440 cites W2622786736 @default.
- W4207045440 cites W2745041761 @default.
- W4207045440 cites W2746288049 @default.
- W4207045440 cites W2757304468 @default.
- W4207045440 cites W2766541644 @default.
- W4207045440 cites W2789740507 @default.
- W4207045440 cites W2790671224 @default.
- W4207045440 cites W2806511317 @default.
- W4207045440 cites W2811081018 @default.
- W4207045440 cites W2902450001 @default.
- W4207045440 cites W2909781189 @default.