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- W4207046183 abstract "Growth factors stimulate specific receptor tyrosine kinases, but subsequent receptor endocytosis terminates signaling. The ubiquitin ligase c-Cbl targets epidermal growth factor receptors (EGFRs) to endocytosis by tagging them with multiple ubiquitin molecules. However, the type of ubiquitylation is unknown; whereas polyubiquitin chains signal proteasomal degradation, ubiquitin monomers control other processes. We report that in isolation c-Cbl mediates monoubiquitylation rather than polyubiquitylation of EGFRs. Consistent with the sufficiency of monoubiquitylation, when fused to the tail of EGFR, a single ubiquitin induces receptor endocytosis and degradation in cells. By using receptor and ubiquitin mutants, we infer that c-Cbl attaches a founder monoubiquitin to the kinase domain of EGFR and this is complemented by the conjugation of additional monoubiquitins. Hence, receptor tyrosine kinases are desensitized through conjugation of multiple monoubiquitins, which is distinct from polyubiquitin-dependent proteasomal degradation. PMID: 12719435 Funding information This work was supported by: NCI NIH HHS, United States Grant ID: CA 72981" @default.
- W4207046183 created "2022-01-26" @default.
- W4207046183 creator A5070933720 @default.
- W4207046183 date "2003-05-16" @default.
- W4207046183 modified "2023-09-23" @default.
- W4207046183 title "Faculty Opinions recommendation of Endocytosis of receptor tyrosine kinases is driven by monoubiquitylation, not polyubiquitylation." @default.
- W4207046183 doi "https://doi.org/10.3410/f.1013416.190554" @default.
- W4207046183 hasPublicationYear "2003" @default.
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