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- W4207046329 endingPage "2844" @default.
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- W4207046329 abstract "Algae are a large group of photosynthetic organisms responsible for approximately half of the earth's total photosynthesis. In addition to their fundamental ecological roles as oxygen producers and as the food base for almost all aquatic life, algae are also a rich source of bioactive natural products, including several clinical drugs. Cytochrome P450 enzymes (P450s) are a superfamily of biocatalysts that are extensively involved in natural product biosynthesis by mediating various types of reactions. In the post-genome era, a growing number of P450 genes have been discovered from algae, indicating their important roles in algal life-cycle. However, the functional studies of algal P450s remain limited. Benefitting from the recent technical advances in algae cultivation and genetic manipulation, the researches on P450s in algal natural product biosynthesis have been approaching to a new stage. Moreover, some photoautotrophic algae have been developed into “photo-bioreactors” for heterologous P450s to produce high-value added pharmaceuticals and chemicals in a carbon-neutral or carbon-negative manner. Here, we comprehensively review these advances of P450 studies in algae from 2000 to 2021." @default.
- W4207046329 created "2022-01-26" @default.
- W4207046329 creator A5009094417 @default.
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- W4207046329 creator A5071932485 @default.
- W4207046329 date "2022-06-01" @default.
- W4207046329 modified "2023-10-17" @default.
- W4207046329 title "Cytochrome P450s in algae: Bioactive natural product biosynthesis and light-driven bioproduction" @default.
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