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• W4207050591 abstract "Recent studies on three-dimensional (3D) bioprinting of cell-laden gelatin methacryloyl (GelMA) hydrogels have provided promising outcomes for tissue engineering applications. However, the reliance on the use of photo-induced gelation processes for the bioprinting of GelMA and the lack of an alternative crosslinking process remain major challenges for the fabrication of cell-laden structures. Here, we present a novel crosslinking approach to form cell-laden GelMA hydrogel constructs through 3D embedded bioprinting without using any external irradiation that could drastically affect cell viability and functionality. This approach consists of a one-step type of crosslinking via bisulfite-initiated radical polymerization, which is combined with embedded bioprinting technology to improve the structural complexity of printed structures. By this means, complex-shaped hydrogel bio-structures with cell viability higher than 90% were successfully printed within a support bath including sodium bisulfite. This study offers an important alternative to other photo-induced gelation processes to improve the bio-fabrication of GelMA hydrogel with high cell viability." @default.
• W4207050591 created "2022-01-26" @default.
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• W4207050591 date "2022-02-09" @default.
• W4207050591 modified "2023-09-30" @default.
• W4207050591 title "Bisulfite-initiated crosslinking of gelatin methacryloyl hydrogels for embedded 3D bioprinting" @default.
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• W4207050591 doi "https://doi.org/10.1088/1758-5090/ac4dd9" @default.
• W4207050591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35062010" @default.
• W4207050591 hasPublicationYear "2022" @default.
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