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- W4207054003 abstract "Automated optimization algorithm (AdaptivCRT; Medtronic, Mounds View, MN, USA) allowing automated optimization of cardiac resynchronization therapy (CRT), has been introduced. However, little is known concerning its cost-effectiveness. This study aims to evaluate the potential economic benefits of AdaptivCRT of CRT.Markov modelling was informed by empirical data sourced from the AdaptivCRT Clinical Trial. Published meta-analyses were used to derive the impact of increasing response to hospitalization and mortality risks. Response was assessed via the clinical composite score.Deterministic results suggested a mean survival of 10.97 years with adaptive algorithms against 10.5 years without (+0.47 in favour of novel algorithms). Heart failure hospitalization costs were modelled to ¥1,382,753 (US $12,686) with novel devices against ¥1,524,747 (US $13,989) with previous technology models. Sensitivity analyses show CRT with Adaptive algorithm was projected to provide cost savings in all scenarios.The use of AdaptivCRT was projected to improve average patient survival and avoid costs in a Japanese healthcare setting." @default.
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- W4207054003 date "2022-06-01" @default.
- W4207054003 modified "2023-09-26" @default.
- W4207054003 title "Cost-effective analysis of automated programming optimization in cardiac resynchronization therapy: Holistic Markov modelling" @default.
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- W4207054003 doi "https://doi.org/10.1016/j.jjcc.2021.12.016" @default.
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