Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207054489> ?p ?o ?g. }
- W4207054489 endingPage "120304" @default.
- W4207054489 startingPage "120304" @default.
- W4207054489 abstract "The present study aimed to investigate the role of α and β-adrenergic receptors (βARs) in mediation or modulation of the dexamethasone-induced nephrotoxicity by using different pharmacological interventions. Nephrotoxicity was induced by subcutaneous injection of dexamethasone (10 mg/kg) for 7 days in Wistar albino rats. Eight groups were used: control; dexamethasone; carvedilol; phenylephrine; carvedilol and phenylephrine; propranolol; doxazosin; propranolol and doxazosin. At the end of experiment, rats were euthanized and blood, urine and kidney samples were collected. Serum and urinary creatinine and urinary total protein levels were measured. Also, the renal tissue levels of diacylglycerol (DAG); Akt kinase activity, malondialdehyde (MDA), NADPH oxidase 2 (NOX2), transforming growth factor-β (TGF-β), Wnt3A and β-catenin were recorded. Furthermore, histopathological and β-arrestin2-immunohistochemical examinations of renal tissues were performed. Results: Dexamethasone induced glomerular damage, proteinuria, renal oxidative stress and upregulated the renal Wnt/β-arrestin2/β-catenin pathway and the profibrotic signals. Blocking the α1 and βARs by carvedilol reduced the dexamethasone-induced nephrotoxicity. Pre-injection of phenylephrine did not reduce the reno-protective action of carvedilol. Blocking the βARs only by propranolol reduced the dexamethasone-induced nephrotoxicity to the same extent of carvedilol group. Blocking the α1ARs only by doxazosin reduced dexamethasone-induced nephrotoxicity to a higher extent than other treatments. However, combined use of propranolol and doxazosin did not synergize the reno-protective effects of doxazosin. Conclusion: Dexamethasone induces nephrotoxicity, possibly, by upregulating the Wnt/β-arrestin2/β-catenin pathway. Blocking either α1ARs or βARs can effectively protect against the dexamethasone-induced nephrotoxicity. However, combined blocking of α1ARs and βARs does not synergize the reno-protective effects." @default.
- W4207054489 created "2022-01-26" @default.
- W4207054489 creator A5008425140 @default.
- W4207054489 creator A5011341709 @default.
- W4207054489 creator A5017369436 @default.
- W4207054489 creator A5025721649 @default.
- W4207054489 creator A5031177028 @default.
- W4207054489 creator A5032041091 @default.
- W4207054489 creator A5032069147 @default.
- W4207054489 date "2022-03-01" @default.
- W4207054489 modified "2023-10-01" @default.
- W4207054489 title "Mitigation of dexamethasone-induced nephrotoxicity by modulating the activity of adrenergic receptors: Implication of Wnt/β-arrestin2/β-catenin pathway" @default.
- W4207054489 cites W1503765703 @default.
- W4207054489 cites W1633895660 @default.
- W4207054489 cites W1967090561 @default.
- W4207054489 cites W1971424572 @default.
- W4207054489 cites W1972014921 @default.
- W4207054489 cites W1978351901 @default.
- W4207054489 cites W1989021071 @default.
- W4207054489 cites W1993647014 @default.
- W4207054489 cites W2013926666 @default.
- W4207054489 cites W2015008192 @default.
- W4207054489 cites W2015084058 @default.
- W4207054489 cites W2020879180 @default.
- W4207054489 cites W2025547181 @default.
- W4207054489 cites W2030971346 @default.
- W4207054489 cites W2031229030 @default.
- W4207054489 cites W2032918645 @default.
- W4207054489 cites W2033324514 @default.
- W4207054489 cites W2034804787 @default.
- W4207054489 cites W2038150674 @default.
- W4207054489 cites W2045548131 @default.
- W4207054489 cites W2059550743 @default.
- W4207054489 cites W2059668261 @default.
- W4207054489 cites W2060290432 @default.
- W4207054489 cites W2060785208 @default.
- W4207054489 cites W2062550356 @default.
- W4207054489 cites W2064939848 @default.
- W4207054489 cites W2069623518 @default.
- W4207054489 cites W2071454809 @default.
- W4207054489 cites W2072785882 @default.
- W4207054489 cites W2081375534 @default.
- W4207054489 cites W2082485466 @default.
- W4207054489 cites W2109525012 @default.
- W4207054489 cites W2114530999 @default.
- W4207054489 cites W2118136744 @default.
- W4207054489 cites W2118790046 @default.
- W4207054489 cites W2121759271 @default.
- W4207054489 cites W2140154776 @default.
- W4207054489 cites W2146757985 @default.
- W4207054489 cites W2333357722 @default.
- W4207054489 cites W2337906701 @default.
- W4207054489 cites W2410129905 @default.
- W4207054489 cites W2588736812 @default.
- W4207054489 cites W2607373825 @default.
- W4207054489 cites W2781222470 @default.
- W4207054489 cites W2790150914 @default.
- W4207054489 cites W2891050486 @default.
- W4207054489 cites W2921213181 @default.
- W4207054489 cites W2990651527 @default.
- W4207054489 cites W2997217639 @default.
- W4207054489 cites W3005608385 @default.
- W4207054489 cites W3021705661 @default.
- W4207054489 cites W4297776613 @default.
- W4207054489 doi "https://doi.org/10.1016/j.lfs.2022.120304" @default.
- W4207054489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35016879" @default.
- W4207054489 hasPublicationYear "2022" @default.
- W4207054489 type Work @default.
- W4207054489 citedByCount "4" @default.
- W4207054489 countsByYear W42070544892022 @default.
- W4207054489 countsByYear W42070544892023 @default.
- W4207054489 crossrefType "journal-article" @default.
- W4207054489 hasAuthorship W4207054489A5008425140 @default.
- W4207054489 hasAuthorship W4207054489A5011341709 @default.
- W4207054489 hasAuthorship W4207054489A5017369436 @default.
- W4207054489 hasAuthorship W4207054489A5025721649 @default.
- W4207054489 hasAuthorship W4207054489A5031177028 @default.
- W4207054489 hasAuthorship W4207054489A5032041091 @default.
- W4207054489 hasAuthorship W4207054489A5032069147 @default.
- W4207054489 hasConcept C126189478 @default.
- W4207054489 hasConcept C126322002 @default.
- W4207054489 hasConcept C134018914 @default.
- W4207054489 hasConcept C185592680 @default.
- W4207054489 hasConcept C2777590997 @default.
- W4207054489 hasConcept C2777952589 @default.
- W4207054489 hasConcept C2778198053 @default.
- W4207054489 hasConcept C2780091579 @default.
- W4207054489 hasConcept C2780401358 @default.
- W4207054489 hasConcept C2780591200 @default.
- W4207054489 hasConcept C71924100 @default.
- W4207054489 hasConcept C84393581 @default.
- W4207054489 hasConcept C98274493 @default.
- W4207054489 hasConceptScore W4207054489C126189478 @default.
- W4207054489 hasConceptScore W4207054489C126322002 @default.
- W4207054489 hasConceptScore W4207054489C134018914 @default.
- W4207054489 hasConceptScore W4207054489C185592680 @default.
- W4207054489 hasConceptScore W4207054489C2777590997 @default.
- W4207054489 hasConceptScore W4207054489C2777952589 @default.