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- W4207054998 abstract "Thrombosis usually occurs when a blood clot shapes within the blood vessel which may prevent the bloodstream through the body. Earlier microbubbles and tPA-mediated ultrasound thrombolysis usually had a relatively low efficacy for retracted clots owing to the limited penetration of agents into the condensed clot fibrin networks. Here we report the advancement of ultrasound and magnetic dual-mode stacked transducers, which can generate ultrasound wave and high frequency oscillating magnetic field to stimulate the superparamagnetic iron oxide nanoparticles (SPIONs) and microbubbles for enhanced tPA-mediated sonothrombolysis. The results showed that the combined effects of localized hyperthermia from the high-frequency oscillation of SPIONs and mechanical shock waves from ultrasound could effectively enhance the tPA-mediated sonothrombolysis efficacy." @default.
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- W4207054998 date "2021-12-12" @default.
- W4207054998 modified "2023-10-17" @default.
- W4207054998 title "Ultrasound and Magnetic Dual-Mode Stacked Transducer for High-Frequency Magneto-Sonothrombolysis" @default.
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- W4207054998 doi "https://doi.org/10.1109/nmdc50713.2021.9677479" @default.
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