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• W4207055260 endingPage "170" @default.
• W4207055260 startingPage "170" @default.
• W4207055260 abstract "Oxidative stress and neuroinflammation are common bases for disease onset and progression in many neurodegenerative diseases. In Parkinson disease, which is characterized by the degeneration of dopaminergic neurons resulting in dopamine depletion, the pathogenesis differs between hereditary and solitary disease forms and is often unclear. In addition to the pathogenicity of alpha-synuclein as a pathological disease marker, the involvement of dopamine itself and its interactions with glial cells (astrocyte or microglia) have attracted attention. Pacemaking activity, which is a hallmark of dopaminergic neurons, is essential for the homeostatic maintenance of adequate dopamine concentrations in the synaptic cleft, but it imposes a burden on mitochondrial oxidative glucose metabolism, leading to reactive oxygen species production. Astrocytes provide endogenous neuroprotection to the brain by producing and releasing antioxidants in response to oxidative stress. Additionally, the protective function of astrocytes can be modified by microglia. Some types of microglia themselves are thought to exacerbate Parkinson disease by releasing pro-inflammatory factors (M1 microglia). Although these inflammatory microglia may further trigger the inflammatory conversion of astrocytes, microglia may induce astrocytic neuroprotective effects (A2 astrocytes) simultaneously. Interestingly, both astrocytes and microglia express dopamine receptors, which are upregulated in the presence of neuroinflammation. The anti-inflammatory effects of dopamine receptor stimulation are also attracting attention because the functions of astrocytes and microglia are greatly affected by both dopamine depletion and therapeutic dopamine replacement in Parkinson disease. In this review article, we will focus on the antioxidative and anti-inflammatory effects of astrocytes and their synergism with microglia and dopamine." @default.
• W4207055260 created "2022-01-26" @default.
• W4207055260 creator A5023266965 @default.
• W4207055260 creator A5026041458 @default.
• W4207055260 date "2022-01-17" @default.
• W4207055260 modified "2023-10-18" @default.
• W4207055260 title "Neuroprotection and Disease Modification by Astrocytes and Microglia in Parkinson Disease" @default.
• W4207055260 cites W1579609692 @default.
• W4207055260 cites W1683050357 @default.
• W4207055260 cites W1967114933 @default.
• W4207055260 cites W1985292661 @default.
• W4207055260 cites W1997626570 @default.
• W4207055260 cites W2001152160 @default.
• W4207055260 cites W2006200262 @default.
• W4207055260 cites W2008624705 @default.
• W4207055260 cites W2022134767 @default.
• W4207055260 cites W2032163981 @default.
• W4207055260 cites W2037575256 @default.
• W4207055260 cites W2037704797 @default.
• W4207055260 cites W2039824205 @default.
• W4207055260 cites W2048893204 @default.
• W4207055260 cites W2055487345 @default.
• W4207055260 cites W2059463965 @default.
• W4207055260 cites W2063541896 @default.
• W4207055260 cites W2067548955 @default.
• W4207055260 cites W2074818354 @default.
• W4207055260 cites W2077168428 @default.
• W4207055260 cites W2078241081 @default.
• W4207055260 cites W2080853291 @default.
• W4207055260 cites W2087456027 @default.
• W4207055260 cites W2092635505 @default.
• W4207055260 cites W2094633691 @default.
• W4207055260 cites W2101969014 @default.
• W4207055260 cites W2109332387 @default.
• W4207055260 cites W2112948259 @default.
• W4207055260 cites W2113360218 @default.
• W4207055260 cites W2113685911 @default.
• W4207055260 cites W2137500360 @default.
• W4207055260 cites W2137668351 @default.
• W4207055260 cites W2141976392 @default.
• W4207055260 cites W2148611607 @default.
• W4207055260 cites W2155957566 @default.
• W4207055260 cites W2250240315 @default.
• W4207055260 cites W2273168336 @default.
• W4207055260 cites W2347079267 @default.
• W4207055260 cites W2395726366 @default.
• W4207055260 cites W2416301058 @default.
• W4207055260 cites W2470567750 @default.
• W4207055260 cites W2498411827 @default.
• W4207055260 cites W2547387046 @default.
• W4207055260 cites W2572710398 @default.
• W4207055260 cites W2584889633 @default.
• W4207055260 cites W2590465929 @default.
• W4207055260 cites W2605202107 @default.
• W4207055260 cites W2609384628 @default.
• W4207055260 cites W2612808369 @default.
• W4207055260 cites W2724573888 @default.
• W4207055260 cites W2769014311 @default.
• W4207055260 cites W2793701389 @default.
• W4207055260 cites W2800776893 @default.
• W4207055260 cites W2801995663 @default.
• W4207055260 cites W2804113914 @default.
• W4207055260 cites W2819962576 @default.
• W4207055260 cites W2884295712 @default.
• W4207055260 cites W2893887260 @default.
• W4207055260 cites W2899963282 @default.
• W4207055260 cites W2904701356 @default.
• W4207055260 cites W2920849491 @default.
• W4207055260 cites W2927457199 @default.
• W4207055260 cites W2941961532 @default.
• W4207055260 cites W2948995731 @default.
• W4207055260 cites W2954390789 @default.
• W4207055260 cites W2964281414 @default.
• W4207055260 cites W2978283227 @default.
• W4207055260 cites W2986109479 @default.
• W4207055260 cites W2999320389 @default.
• W4207055260 cites W3005241625 @default.
• W4207055260 cites W3005352836 @default.
• W4207055260 cites W3006208753 @default.
• W4207055260 cites W3007594181 @default.
• W4207055260 cites W3011306000 @default.
• W4207055260 cites W3036737730 @default.
• W4207055260 cites W3037575343 @default.
• W4207055260 cites W3045520799 @default.
• W4207055260 cites W3045733764 @default.
• W4207055260 cites W3049318948 @default.
• W4207055260 cites W3080157062 @default.
• W4207055260 cites W3082963664 @default.
• W4207055260 cites W3087201976 @default.
• W4207055260 cites W3092603594 @default.
• W4207055260 cites W3097355334 @default.
• W4207055260 cites W3097880312 @default.
• W4207055260 cites W3109071173 @default.
• W4207055260 cites W3109598442 @default.
• W4207055260 cites W3110935809 @default.
• W4207055260 cites W3111049868 @default.
• W4207055260 cites W3114011859 @default.
• W4207055260 cites W3116421092 @default.

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