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• W4207055608 endingPage "101633" @default.
• W4207055608 startingPage "101633" @default.
• W4207055608 abstract "Most transcription factors possess at least one long intrinsically disordered transactivation domain that binds to a variety of coactivators and corepressors and plays a key role in modulating the transcriptional activity. Despite the crucial importance of these domains, the structural and functional basis of transactivation remains poorly understood. Here, we focused on activating transcription factor 4 (ATF4)/cAMP response element-binding protein-2, an essential transcription factor for cellular stress adaptation. Bioinformatic sequence analysis of the ATF4 transactivation domain sequence revealed that the first 125 amino acids have noticeably less propensity for structural disorder than the rest of the domain. Using solution nuclear magnetic resonance spectroscopy complemented by a range of biophysical methods, we found that the isolated transactivation domain is predominantly yet not fully disordered in solution. We also observed that a short motif at the N-terminus of the transactivation domain has a high helical propensity. Importantly, we found that the N-terminal region of the transactivation domain is involved in transient long-range interactions with the basic-leucine zipper domain involved in DNA binding. Finally, in vitro phosphorylation assays with the casein kinase 2 show that the presence of the basic-leucine zipper domain is required for phosphorylation of the transactivation domain. This study uncovers the intricate coupling existing between the transactivation and basic-leucine zipper domains of ATF4, highlighting its potential regulatory significance." @default.
• W4207055608 created "2022-01-26" @default.
• W4207055608 creator A5020901311 @default.
• W4207055608 creator A5026909965 @default.
• W4207055608 creator A5045323375 @default.
• W4207055608 date "2022-03-01" @default.
• W4207055608 modified "2023-09-30" @default.
• W4207055608 title "Intricate coupling between the transactivation and basic-leucine zipper domains governs phosphorylation of transcription factor ATF4 by casein kinase 2" @default.
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• W4207055608 doi "https://doi.org/10.1016/j.jbc.2022.101633" @default.
• W4207055608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35077711" @default.
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