Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207056181> ?p ?o ?g. }
- W4207056181 abstract "Sterile inflammation characterized by unresolved chronic inflammation is well established to promote the progression of multiple autoimmune diseases, metabolic disorders, neurodegenerative diseases, and cardiovascular diseases, collectively termed 'sterile inflammatory diseases'. By recognizing host-derived DNA, cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) activates endoplasmic reticulum-associated stimulator of interferon genes (STING), which leads to the induction of type I interferons and inflammatory cytokines or immunogenic cell death that promotes sterile inflammation. Additionally, the DNA/cGAS-independent mode of STING activation has also been characterized in the progression of several sterile inflammatory diseases. This review focuses on the molecular mechanism of cGAS-dependent and cGAS-independent STING signaling under various disease conditions, particularly highlighting the diverse initiators upon this signaling pathway. We also summarize recent advances in the discovery of antagonists targeting cGAS and STING and the evaluation of their efficiencies in preclinical models. Finally, we discuss potential differences in the clinical applications of the specific antagonists, which may shed light on the precision therapeutic interventions." @default.
- W4207056181 created "2022-01-26" @default.
- W4207056181 creator A5013038112 @default.
- W4207056181 creator A5015515628 @default.
- W4207056181 creator A5069994669 @default.
- W4207056181 creator A5070317068 @default.
- W4207056181 creator A5081349852 @default.
- W4207056181 date "2022-01-27" @default.
- W4207056181 modified "2023-10-18" @default.
- W4207056181 title "Intervention of cGAS‒STING signaling in sterile inflammatory diseases" @default.
- W4207056181 cites W1559117436 @default.
- W4207056181 cites W1594574415 @default.
- W4207056181 cites W1966408457 @default.
- W4207056181 cites W1993860509 @default.
- W4207056181 cites W2003034886 @default.
- W4207056181 cites W2015310325 @default.
- W4207056181 cites W2031182394 @default.
- W4207056181 cites W2035232303 @default.
- W4207056181 cites W2044330780 @default.
- W4207056181 cites W2046640968 @default.
- W4207056181 cites W2060004514 @default.
- W4207056181 cites W2063675796 @default.
- W4207056181 cites W2066818317 @default.
- W4207056181 cites W2072510538 @default.
- W4207056181 cites W2083147016 @default.
- W4207056181 cites W2088157683 @default.
- W4207056181 cites W2091144643 @default.
- W4207056181 cites W2093268266 @default.
- W4207056181 cites W2097750604 @default.
- W4207056181 cites W2099610218 @default.
- W4207056181 cites W2114737175 @default.
- W4207056181 cites W2116527093 @default.
- W4207056181 cites W2118095236 @default.
- W4207056181 cites W2119864130 @default.
- W4207056181 cites W2123645680 @default.
- W4207056181 cites W2124451653 @default.
- W4207056181 cites W2147701649 @default.
- W4207056181 cites W2150715314 @default.
- W4207056181 cites W2165748936 @default.
- W4207056181 cites W2170295495 @default.
- W4207056181 cites W2261479737 @default.
- W4207056181 cites W2282960029 @default.
- W4207056181 cites W2419219541 @default.
- W4207056181 cites W2469317767 @default.
- W4207056181 cites W2503400905 @default.
- W4207056181 cites W2513658500 @default.
- W4207056181 cites W2547204916 @default.
- W4207056181 cites W2570842995 @default.
- W4207056181 cites W2593144838 @default.
- W4207056181 cites W2597238176 @default.
- W4207056181 cites W2597555000 @default.
- W4207056181 cites W2606232917 @default.
- W4207056181 cites W2742007963 @default.
- W4207056181 cites W2743873195 @default.
- W4207056181 cites W2756540989 @default.
- W4207056181 cites W2758637781 @default.
- W4207056181 cites W2759921274 @default.
- W4207056181 cites W2761362534 @default.
- W4207056181 cites W2762611634 @default.
- W4207056181 cites W2765921352 @default.
- W4207056181 cites W2767983921 @default.
- W4207056181 cites W2768387192 @default.
- W4207056181 cites W2772071335 @default.
- W4207056181 cites W2773964572 @default.
- W4207056181 cites W2785371802 @default.
- W4207056181 cites W2788480107 @default.
- W4207056181 cites W2792032274 @default.
- W4207056181 cites W2793039873 @default.
- W4207056181 cites W2800025479 @default.
- W4207056181 cites W2800255316 @default.
- W4207056181 cites W2803376047 @default.
- W4207056181 cites W2809821375 @default.
- W4207056181 cites W2810612816 @default.
- W4207056181 cites W2883721603 @default.
- W4207056181 cites W2884661296 @default.
- W4207056181 cites W2885309985 @default.
- W4207056181 cites W2887997888 @default.
- W4207056181 cites W2891103014 @default.
- W4207056181 cites W2900220188 @default.
- W4207056181 cites W2904021876 @default.
- W4207056181 cites W2904365141 @default.
- W4207056181 cites W2904651186 @default.
- W4207056181 cites W2905091095 @default.
- W4207056181 cites W2906051249 @default.
- W4207056181 cites W2909164374 @default.
- W4207056181 cites W2911642321 @default.
- W4207056181 cites W2916717448 @default.
- W4207056181 cites W2916856097 @default.
- W4207056181 cites W2918490000 @default.
- W4207056181 cites W2919692138 @default.
- W4207056181 cites W2919704769 @default.
- W4207056181 cites W2919896467 @default.
- W4207056181 cites W2921248996 @default.
- W4207056181 cites W2921681769 @default.
- W4207056181 cites W2921875691 @default.
- W4207056181 cites W2924757324 @default.
- W4207056181 cites W2925918354 @default.
- W4207056181 cites W2945498322 @default.
- W4207056181 cites W2945993260 @default.
- W4207056181 cites W2950099887 @default.