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- W4207060051 endingPage "114115" @default.
- W4207060051 startingPage "114115" @default.
- W4207060051 abstract "CNS tumors remain among the deadliest forms of cancer, resisting conventional and new treatment approaches, with mortality rates staying practically unchanged over the past 30 years. One of the primary hurdles for treating these cancers is delivering drugs to the brain tumor site in therapeutic concentration, evading the blood-brain (tumor) barrier (BBB/BBTB). Supramolecular nanomedicines (NMs) are increasingly demonstrating noteworthy prospects for addressing these challenges utilizing their unique characteristics, such as improving the bioavailability of the payloadsviacontrolled pharmacokinetics and pharmacodynamics, BBB/BBTB crossing functions, superior distribution in the brain tumor site, and tumor-specific drug activation profiles. Here, we review NM-based brain tumor targeting approaches to demonstrate their applicability and translation potential from different perspectives. To this end, we provide a general overview of brain tumor and their treatments, the incidence of the BBB and BBTB, and their role on NM targeting, as well as the potential of NMs for promoting superior therapeutic effects. Additionally, we discuss critical issues of NMs and their clinical trials, aiming to bolster the potential clinical applications of NMs in treating these life-threatening diseases." @default.
- W4207060051 created "2022-01-26" @default.
- W4207060051 creator A5015097923 @default.
- W4207060051 creator A5056964526 @default.
- W4207060051 creator A5075887548 @default.
- W4207060051 date "2022-03-01" @default.
- W4207060051 modified "2023-10-17" @default.
- W4207060051 title "Nanomedicine for brain cancer" @default.
- W4207060051 cites W102542875 @default.
- W4207060051 cites W118686632 @default.
- W4207060051 cites W1210551670 @default.
- W4207060051 cites W1512493964 @default.
- W4207060051 cites W1528827595 @default.
- W4207060051 cites W1541574343 @default.
- W4207060051 cites W1553534857 @default.
- W4207060051 cites W1567125309 @default.
- W4207060051 cites W1575993552 @default.
- W4207060051 cites W1604955250 @default.
- W4207060051 cites W1645188448 @default.
- W4207060051 cites W1792338879 @default.
- W4207060051 cites W1815157104 @default.
- W4207060051 cites W1896246110 @default.
- W4207060051 cites W1937925273 @default.
- W4207060051 cites W1965130745 @default.
- W4207060051 cites W1965403161 @default.
- W4207060051 cites W1966537386 @default.
- W4207060051 cites W1966656255 @default.
- W4207060051 cites W1966743152 @default.
- W4207060051 cites W1969226057 @default.
- W4207060051 cites W1970300303 @default.
- W4207060051 cites W1971040598 @default.
- W4207060051 cites W1972613027 @default.
- W4207060051 cites W1978516071 @default.
- W4207060051 cites W1982904297 @default.
- W4207060051 cites W1983946589 @default.
- W4207060051 cites W1984007145 @default.
- W4207060051 cites W1984262875 @default.
- W4207060051 cites W1984482190 @default.
- W4207060051 cites W1985858988 @default.
- W4207060051 cites W1991505853 @default.
- W4207060051 cites W1992457036 @default.
- W4207060051 cites W1993239010 @default.
- W4207060051 cites W1993463179 @default.
- W4207060051 cites W1993716605 @default.
- W4207060051 cites W1995596330 @default.
- W4207060051 cites W1996719014 @default.
- W4207060051 cites W1996827572 @default.
- W4207060051 cites W1996963479 @default.
- W4207060051 cites W1997449859 @default.
- W4207060051 cites W1999620450 @default.
- W4207060051 cites W2001257757 @default.
- W4207060051 cites W2002516695 @default.
- W4207060051 cites W2002934128 @default.
- W4207060051 cites W2004062257 @default.
- W4207060051 cites W2005044853 @default.
- W4207060051 cites W2010587462 @default.
- W4207060051 cites W2011139878 @default.
- W4207060051 cites W2011642035 @default.
- W4207060051 cites W2012681969 @default.
- W4207060051 cites W2015343062 @default.
- W4207060051 cites W2016612145 @default.
- W4207060051 cites W2018101112 @default.
- W4207060051 cites W2019318549 @default.
- W4207060051 cites W2020217107 @default.
- W4207060051 cites W2021513663 @default.
- W4207060051 cites W2024197754 @default.
- W4207060051 cites W2024533743 @default.
- W4207060051 cites W2024636481 @default.
- W4207060051 cites W2024802832 @default.
- W4207060051 cites W2025910324 @default.
- W4207060051 cites W2027971541 @default.
- W4207060051 cites W2030932194 @default.
- W4207060051 cites W2032043292 @default.
- W4207060051 cites W2033835457 @default.
- W4207060051 cites W2033847281 @default.
- W4207060051 cites W2035437489 @default.
- W4207060051 cites W2035833975 @default.
- W4207060051 cites W2038859753 @default.
- W4207060051 cites W2039881069 @default.
- W4207060051 cites W2041016185 @default.
- W4207060051 cites W2043481243 @default.
- W4207060051 cites W2045564059 @default.
- W4207060051 cites W2047380913 @default.
- W4207060051 cites W2051349300 @default.
- W4207060051 cites W2056529275 @default.
- W4207060051 cites W2062936534 @default.
- W4207060051 cites W2063098625 @default.
- W4207060051 cites W2065379973 @default.
- W4207060051 cites W2066076463 @default.
- W4207060051 cites W2068485719 @default.
- W4207060051 cites W2071112219 @default.
- W4207060051 cites W2078308242 @default.
- W4207060051 cites W2081560282 @default.
- W4207060051 cites W2082587127 @default.
- W4207060051 cites W2083274084 @default.
- W4207060051 cites W2083710155 @default.
- W4207060051 cites W2087414776 @default.
- W4207060051 cites W2087801719 @default.