FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207060819> ?p ?o ?g. }

• W4207060819 endingPage "100112" @default.
• W4207060819 startingPage "100112" @default.
• W4207060819 abstract "We have previously reported a multipurpose silicone elastomer vaginal ring providing sustained release of dapivirine (an antiretroviral) and levonorgestrel (a progestin) for HIV prevention and hormonal contraception. During initial development, issues arose due to reaction between the ethynyl group in the levonorgestrel molecule and the hydride-functionalised polydimethylsiloxane components in the silicone elastomer formulation. This unwanted reaction occurred both during and to a lesser extent after ring manufacture, impacting the curing process, the mechanical properties of the ring, and the in vitro release of levonorgestrel. Recently, we reported custom silicone elastomer grades that minimise this reaction. In this follow-on study, we describe the manufacture, in vitro drug release, mechanical, and pharmaceutical stability testing of ring formulations prepared from a custom silicone elastomer and containing 200 mg dapivirine and 80, 160, 240 or 320 mg levonorgestrel. The rings showed mechanical properties similar to marketed ring products, sustained in vitro release of both drugs over 30 days in quantities deemed clinically relevant, offered acceptable assay values, and provided good product stability over 15 weeks at 40 °C and 75% relative humidity." @default.
• W4207060819 created "2022-01-26" @default.
• W4207060819 creator A5003451904 @default.
• W4207060819 creator A5004311918 @default.
• W4207060819 creator A5008667087 @default.
• W4207060819 creator A5025259683 @default.
• W4207060819 creator A5026538989 @default.
• W4207060819 creator A5028821578 @default.
• W4207060819 creator A5035324611 @default.
• W4207060819 creator A5051310947 @default.
• W4207060819 creator A5062483846 @default.
• W4207060819 creator A5067331138 @default.
• W4207060819 creator A5080498230 @default.
• W4207060819 creator A5087686612 @default.
• W4207060819 creator A5089728263 @default.
• W4207060819 date "2022-12-01" @default.
• W4207060819 modified "2023-10-17" @default.
• W4207060819 title "In vitro drug release, mechanical performance and stability testing of a custom silicone elastomer vaginal ring releasing dapivirine and levonorgestrel" @default.
• W4207060819 cites W1974260647 @default.
• W4207060819 cites W1974764886 @default.
• W4207060819 cites W1985096708 @default.
• W4207060819 cites W1985334490 @default.
• W4207060819 cites W2001211063 @default.
• W4207060819 cites W2003411287 @default.
• W4207060819 cites W2012286455 @default.
• W4207060819 cites W2017638217 @default.
• W4207060819 cites W2064656069 @default.
• W4207060819 cites W2109302198 @default.
• W4207060819 cites W2134174370 @default.
• W4207060819 cites W2279856658 @default.
• W4207060819 cites W2289924804 @default.
• W4207060819 cites W2290010664 @default.
• W4207060819 cites W2498394961 @default.
• W4207060819 cites W2558446330 @default.
• W4207060819 cites W2811198017 @default.
• W4207060819 cites W2884844093 @default.
• W4207060819 cites W2884865222 @default.
• W4207060819 cites W2889370966 @default.
• W4207060819 cites W2890523744 @default.
• W4207060819 cites W2892511292 @default.
• W4207060819 cites W2895147654 @default.
• W4207060819 cites W2909793001 @default.
• W4207060819 cites W2966613725 @default.
• W4207060819 cites W2980442260 @default.
• W4207060819 cites W2981180224 @default.
• W4207060819 cites W3008799124 @default.
• W4207060819 cites W3041655274 @default.
• W4207060819 cites W3126829155 @default.
• W4207060819 cites W3127596325 @default.
• W4207060819 cites W3205151546 @default.
• W4207060819 doi "https://doi.org/10.1016/j.ijpx.2022.100112" @default.
• W4207060819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35128382" @default.
• W4207060819 hasPublicationYear "2022" @default.
• W4207060819 type Work @default.
• W4207060819 citedByCount "0" @default.
• W4207060819 crossrefType "journal-article" @default.
• W4207060819 hasAuthorship W4207060819A5003451904 @default.
• W4207060819 hasAuthorship W4207060819A5004311918 @default.
• W4207060819 hasAuthorship W4207060819A5008667087 @default.
• W4207060819 hasAuthorship W4207060819A5025259683 @default.
• W4207060819 hasAuthorship W4207060819A5026538989 @default.
• W4207060819 hasAuthorship W4207060819A5028821578 @default.
• W4207060819 hasAuthorship W4207060819A5035324611 @default.
• W4207060819 hasAuthorship W4207060819A5051310947 @default.
• W4207060819 hasAuthorship W4207060819A5062483846 @default.
• W4207060819 hasAuthorship W4207060819A5067331138 @default.
• W4207060819 hasAuthorship W4207060819A5080498230 @default.
• W4207060819 hasAuthorship W4207060819A5087686612 @default.
• W4207060819 hasAuthorship W4207060819A5089728263 @default.
• W4207060819 hasBestOaLocation W42070608191 @default.
• W4207060819 hasConcept C159985019 @default.
• W4207060819 hasConcept C185592680 @default.
• W4207060819 hasConcept C192562407 @default.
• W4207060819 hasConcept C2779076696 @default.
• W4207060819 hasConcept C2779755712 @default.
• W4207060819 hasConcept C2779769944 @default.
• W4207060819 hasConcept C2779849746 @default.
• W4207060819 hasConcept C2780186607 @default.
• W4207060819 hasConcept C2908647359 @default.
• W4207060819 hasConcept C2986817661 @default.
• W4207060819 hasConcept C38052585 @default.
• W4207060819 hasConcept C71924100 @default.
• W4207060819 hasConcept C99454951 @default.
• W4207060819 hasConceptScore W4207060819C159985019 @default.
• W4207060819 hasConceptScore W4207060819C185592680 @default.
• W4207060819 hasConceptScore W4207060819C192562407 @default.
• W4207060819 hasConceptScore W4207060819C2779076696 @default.
• W4207060819 hasConceptScore W4207060819C2779755712 @default.
• W4207060819 hasConceptScore W4207060819C2779769944 @default.
• W4207060819 hasConceptScore W4207060819C2779849746 @default.
• W4207060819 hasConceptScore W4207060819C2780186607 @default.
• W4207060819 hasConceptScore W4207060819C2908647359 @default.
• W4207060819 hasConceptScore W4207060819C2986817661 @default.
• W4207060819 hasConceptScore W4207060819C38052585 @default.
• W4207060819 hasConceptScore W4207060819C71924100 @default.
• W4207060819 hasConceptScore W4207060819C99454951 @default.
• W4207060819 hasLocation W42070608191 @default.
• W4207060819 hasLocation W42070608192 @default.

• next