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- W4207060939 endingPage "119145" @default.
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- W4207060939 abstract "Polysaccharide-based hydrogels are achieving remarkable performances in chronic wounds treatment. In this work, a carboxymethyl cellulose-based hydrogel film was developed to support skin repair. The hydrogel was loaded with berberine, a polyphenolic molecule endowing antioxidant and cytoprotective features. The film was physico-chemically characterized and in vitro tested on keratinocytes and fibroblasts subjected to oxidative stress. The biocomposite showed high thermal stability (onset decomposition temperature 245 °C) and significant fluid uptake performances, both in free conditions (up to 6510%) and under external pressure (up to 3400%). Moreover, it was able to control oxidative stress and inflammation markers involved in wound chronicity. Keratinocytes hyperproliferation, features that normally hamper injury restoration, was reduced of 25%. Our results showed that the combination of berberine and hydrogel provides a synergic improvement of the material properties. The biocomposite represents a promising candidate for dermatological applications against oxidative stress at the chronic wound site, promoting the healing process." @default.
- W4207060939 created "2022-01-26" @default.
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- W4207060939 date "2022-05-01" @default.
- W4207060939 modified "2023-10-17" @default.
- W4207060939 title "Carboxymethyl cellulose-based hydrogel film combined with berberine as an innovative tool for chronic wound management" @default.
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- W4207060939 doi "https://doi.org/10.1016/j.carbpol.2022.119145" @default.
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