Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207064092> ?p ?o ?g. }
- W4207064092 endingPage "109326" @default.
- W4207064092 startingPage "109326" @default.
- W4207064092 abstract "Adolescent marijuana (MJ) use has been associated with alterations in brain structure and function as well as behavior. Examination of neurochemical correlates such as GABA (gamma-aminobutyric acid) and Glx (glutamate + glutamine) in MJ users remains limited. Impulsivity, identified as a risk factor and consequence of MJ use, has been associated with GABA and Glx levels in healthy and clinical populations. However, this relationship has not been investigated in MJ users. In this study, we examined levels of GABA and Glx in the anterior cingulate cortex (ACC) and its relationship with impulsive behavior in MJ-using adolescents and healthy controls. Healthy control subjects (HC; N = 21) and MJ-using adolescents (N = 18) completed a metabolite-edited 1H MRS exam to measure ACC GABA and Glx levels, a structured clinical interview to assess MJ use, and the Barratt Impulsivity Scale (BIS-11) to evaluate impulsive behavior. Adolescent MJ users had significantly lower tissue-corrected GABA (with macromolecules; GABA+) levels (p = 0.029) compared to HC’s. No significant between-group differences were observed in ACC Glx levels. Assessment of impulsive behavior demonstrated no significant between-group differences in motor, non-planning, attention, and total impulsivity scores. Additionally, impulsivity measures and tissue-corrected GABA+ or Glx levels were not significantly correlated in either group. Lower GABA levels in MJ users may indicate alterations in excitatory-inhibitory mechanisms critical for neurodevelopment. Although no significant relationships were observed between impulsive measures and GABA or Glx levels in both groups, further investigations are needed examining the relationship between neurochemical correlates, behavior, and adolescent MJ use." @default.
- W4207064092 created "2022-01-26" @default.
- W4207064092 creator A5000221223 @default.
- W4207064092 creator A5045509647 @default.
- W4207064092 creator A5049878826 @default.
- W4207064092 creator A5057767291 @default.
- W4207064092 creator A5066154447 @default.
- W4207064092 date "2022-04-01" @default.
- W4207064092 modified "2023-10-16" @default.
- W4207064092 title "Examination of gamma-aminobutyric acid and glutamate-glutamine levels in association with impulsive behavior in adolescent marijuana users" @default.
- W4207064092 cites W1411549769 @default.
- W4207064092 cites W1557485257 @default.
- W4207064092 cites W1957708244 @default.
- W4207064092 cites W1964201164 @default.
- W4207064092 cites W1971355386 @default.
- W4207064092 cites W1978267551 @default.
- W4207064092 cites W1979049044 @default.
- W4207064092 cites W1979890059 @default.
- W4207064092 cites W1989333934 @default.
- W4207064092 cites W1990301502 @default.
- W4207064092 cites W2007475108 @default.
- W4207064092 cites W2010351733 @default.
- W4207064092 cites W2015672330 @default.
- W4207064092 cites W2019393387 @default.
- W4207064092 cites W2019643856 @default.
- W4207064092 cites W2021681753 @default.
- W4207064092 cites W2028932421 @default.
- W4207064092 cites W2044231855 @default.
- W4207064092 cites W2050726985 @default.
- W4207064092 cites W2054515032 @default.
- W4207064092 cites W2057540122 @default.
- W4207064092 cites W2059129138 @default.
- W4207064092 cites W2059421922 @default.
- W4207064092 cites W2067461838 @default.
- W4207064092 cites W2075089906 @default.
- W4207064092 cites W2075128941 @default.
- W4207064092 cites W2082454730 @default.
- W4207064092 cites W2085364760 @default.
- W4207064092 cites W2089419894 @default.
- W4207064092 cites W2097747770 @default.
- W4207064092 cites W2106592748 @default.
- W4207064092 cites W2112913710 @default.
- W4207064092 cites W2113928639 @default.
- W4207064092 cites W2126918303 @default.
- W4207064092 cites W2129560479 @default.
- W4207064092 cites W2132002235 @default.
- W4207064092 cites W2139338479 @default.
- W4207064092 cites W2140164239 @default.
- W4207064092 cites W2143384095 @default.
- W4207064092 cites W2165893550 @default.
- W4207064092 cites W2169232412 @default.
- W4207064092 cites W2253496291 @default.
- W4207064092 cites W2513117972 @default.
- W4207064092 cites W2522870798 @default.
- W4207064092 cites W2543073941 @default.
- W4207064092 cites W2563801049 @default.
- W4207064092 cites W2566803638 @default.
- W4207064092 cites W2732817546 @default.
- W4207064092 cites W2736640449 @default.
- W4207064092 cites W2753508364 @default.
- W4207064092 cites W2763712948 @default.
- W4207064092 cites W2768760171 @default.
- W4207064092 cites W2897774008 @default.
- W4207064092 cites W2943622116 @default.
- W4207064092 cites W2945886864 @default.
- W4207064092 cites W2946910244 @default.
- W4207064092 cites W2970377463 @default.
- W4207064092 cites W2971367505 @default.
- W4207064092 cites W2980054010 @default.
- W4207064092 cites W2994997975 @default.
- W4207064092 cites W3003953083 @default.
- W4207064092 cites W3021433232 @default.
- W4207064092 cites W3025730343 @default.
- W4207064092 cites W3081479150 @default.
- W4207064092 doi "https://doi.org/10.1016/j.drugalcdep.2022.109326" @default.
- W4207064092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35131529" @default.
- W4207064092 hasPublicationYear "2022" @default.
- W4207064092 type Work @default.
- W4207064092 citedByCount "1" @default.
- W4207064092 crossrefType "journal-article" @default.
- W4207064092 hasAuthorship W4207064092A5000221223 @default.
- W4207064092 hasAuthorship W4207064092A5045509647 @default.
- W4207064092 hasAuthorship W4207064092A5049878826 @default.
- W4207064092 hasAuthorship W4207064092A5057767291 @default.
- W4207064092 hasAuthorship W4207064092A5066154447 @default.
- W4207064092 hasBestOaLocation W42070640922 @default.
- W4207064092 hasConcept C126322002 @default.
- W4207064092 hasConcept C134018914 @default.
- W4207064092 hasConcept C15744967 @default.
- W4207064092 hasConcept C169760540 @default.
- W4207064092 hasConcept C169900460 @default.
- W4207064092 hasConcept C170493617 @default.
- W4207064092 hasConcept C185592680 @default.
- W4207064092 hasConcept C25876315 @default.
- W4207064092 hasConcept C2777771985 @default.
- W4207064092 hasConcept C2778402161 @default.
- W4207064092 hasConcept C2779264955 @default.
- W4207064092 hasConcept C2779349466 @default.