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- W4207064199 abstract "Antibody-antigen (Ab-Ag) interactions are canonically described by a model that exclusively accommodates noninteraction (0) or reproducible interaction (RI) states, yet this model is inadequate to explain often-encountered nonreproducible signals. Here, by monitoring diverse experimental systems using a peptide-protein hybrid microarray, we observed that Ab-probe interactions comprise a substantial proportion of nonreproducible antibody-based results. This enabled our discovery and capacity to reliably identify nonreproducible Ab-probe interactions (NRIs), as well as our development of a powerful explanatory model (0-NRI-RI-Hook four-state model) that is mAb concentration-dependent, regardless of specificity, which ultimately shows that both nonspecific interactions and NRIs are not predictable yet certain to happen. Our discoveries challenge the centrality of Ab-Ag interaction specificity data in serology and immunology." @default.
- W4207064199 created "2022-01-26" @default.
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- W4207064199 date "2022-01-19" @default.
- W4207064199 modified "2023-10-18" @default.
- W4207064199 title "Previously Unrecognized Nonreproducible Antibody–Probe Interactions" @default.
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- W4207064199 doi "https://doi.org/10.1021/acs.analchem.1c03264" @default.
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