Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207065717> ?p ?o ?g. }
- W4207065717 abstract "SARS-CoV-2 provokes a brisk T cell response. Peptide-based studies exclude antigen processing and presentation biology and may influence T cell detection studies. To focus on responses to whole virus and complex antigens, we used intact SARS-CoV-2 and full-length proteins with DC to activate CD8 and CD4 T cells from convalescent persons. T cell receptor (TCR) sequencing showed partial repertoire preservation after expansion. Resultant CD8 T cells recognize SARS-CoV-2-infected respiratory cells, and CD4 T cells detect inactivated whole viral antigen. Specificity scans with proteome-covering protein/peptide arrays show that CD8 T cells are oligospecific per subject and that CD4 T cell breadth is higher. Some CD4 T cell lines enriched using SARS-CoV-2 cross-recognize whole seasonal coronavirus (sCoV) antigens, with protein, peptide, and HLA restriction validation. Conversely, recognition of some epitopes is eliminated for SARS-CoV-2 variants, including spike (S) epitopes in the alpha, beta, gamma, and delta variant lineages." @default.
- W4207065717 created "2022-01-26" @default.
- W4207065717 creator A5003234648 @default.
- W4207065717 creator A5004397124 @default.
- W4207065717 creator A5012518718 @default.
- W4207065717 creator A5014605629 @default.
- W4207065717 creator A5016681938 @default.
- W4207065717 creator A5021425965 @default.
- W4207065717 creator A5022237358 @default.
- W4207065717 creator A5029307386 @default.
- W4207065717 creator A5030600192 @default.
- W4207065717 creator A5031994519 @default.
- W4207065717 creator A5037916190 @default.
- W4207065717 creator A5046160946 @default.
- W4207065717 creator A5046844992 @default.
- W4207065717 creator A5052928140 @default.
- W4207065717 creator A5053803470 @default.
- W4207065717 creator A5055498658 @default.
- W4207065717 creator A5067646470 @default.
- W4207065717 creator A5073176286 @default.
- W4207065717 date "2022-01-25" @default.
- W4207065717 modified "2023-10-01" @default.
- W4207065717 title "T cell response to intact SARS-CoV-2 includes coronavirus cross-reactive and variant-specific components" @default.
- W4207065717 cites W1887482810 @default.
- W4207065717 cites W1920649539 @default.
- W4207065717 cites W1969481503 @default.
- W4207065717 cites W2038712791 @default.
- W4207065717 cites W2045010575 @default.
- W4207065717 cites W2047272183 @default.
- W4207065717 cites W2053707749 @default.
- W4207065717 cites W2070684866 @default.
- W4207065717 cites W2095899901 @default.
- W4207065717 cites W2098713380 @default.
- W4207065717 cites W2101356848 @default.
- W4207065717 cites W2101976092 @default.
- W4207065717 cites W2102237050 @default.
- W4207065717 cites W2103548051 @default.
- W4207065717 cites W2130766119 @default.
- W4207065717 cites W2131682431 @default.
- W4207065717 cites W2156701272 @default.
- W4207065717 cites W2164989695 @default.
- W4207065717 cites W2252301909 @default.
- W4207065717 cites W2254326086 @default.
- W4207065717 cites W2268663278 @default.
- W4207065717 cites W2416766872 @default.
- W4207065717 cites W2469746525 @default.
- W4207065717 cites W2605343262 @default.
- W4207065717 cites W2978602862 @default.
- W4207065717 cites W2985864725 @default.
- W4207065717 cites W3011138563 @default.
- W4207065717 cites W3026002191 @default.
- W4207065717 cites W3033029188 @default.
- W4207065717 cites W3034071161 @default.
- W4207065717 cites W3036361557 @default.
- W4207065717 cites W3037945517 @default.
- W4207065717 cites W3042183476 @default.
- W4207065717 cites W3043391491 @default.
- W4207065717 cites W3045737895 @default.
- W4207065717 cites W3045971896 @default.
- W4207065717 cites W3046964312 @default.
- W4207065717 cites W3047159181 @default.
- W4207065717 cites W3047277914 @default.
- W4207065717 cites W3047483639 @default.
- W4207065717 cites W3048849008 @default.
- W4207065717 cites W3049464942 @default.
- W4207065717 cites W3082438395 @default.
- W4207065717 cites W3089759643 @default.
- W4207065717 cites W3090049663 @default.
- W4207065717 cites W3090209951 @default.
- W4207065717 cites W3092762305 @default.
- W4207065717 cites W3093824751 @default.
- W4207065717 cites W3095375824 @default.
- W4207065717 cites W3096967708 @default.
- W4207065717 cites W3104722250 @default.
- W4207065717 cites W3107494957 @default.
- W4207065717 cites W3108193091 @default.
- W4207065717 cites W3108668552 @default.
- W4207065717 cites W3111281430 @default.
- W4207065717 cites W3111465292 @default.
- W4207065717 cites W3115163512 @default.
- W4207065717 cites W3116162797 @default.
- W4207065717 cites W3119163550 @default.
- W4207065717 cites W3119858919 @default.
- W4207065717 cites W3122458452 @default.
- W4207065717 cites W3125185876 @default.
- W4207065717 cites W3125404264 @default.
- W4207065717 cites W3125525522 @default.
- W4207065717 cites W3127143267 @default.
- W4207065717 cites W3127852352 @default.
- W4207065717 cites W3127885005 @default.
- W4207065717 cites W3128756947 @default.
- W4207065717 cites W3130121964 @default.
- W4207065717 cites W3132938113 @default.
- W4207065717 cites W3133789246 @default.
- W4207065717 cites W3134208712 @default.
- W4207065717 cites W3134245065 @default.
- W4207065717 cites W3134489892 @default.
- W4207065717 cites W3134643257 @default.
- W4207065717 cites W3136947871 @default.
- W4207065717 cites W3137307037 @default.