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- W4207066160 endingPage "106763" @default.
- W4207066160 startingPage "106763" @default.
- W4207066160 abstract "MicroRNAs (miRNAs) are important regulators of post-transcriptional gene expression. Mature miRNAs are generated from longer transcripts (primary, pri- and precursor, pre-miRNAs) through a series of highly coordinated enzymatic processing steps. The sequence and structure of these pri- and pre-miRNAs play important roles in controlling their processing. Both pri- and pre-miRNAs adopt hairpin structures with imperfect base pairing in the helical stem. Here, we investigated the role of three base pair mismatches (A∙A, G∙A, and C∙A) present in pre-miRNA-31. Using a combination of NMR spectroscopy and thermal denaturation, we found that nucleotides within the three base pair mismatches displayed unique structural properties, including varying dynamics and sensitivity to solution pH. These studies deepen our understanding of how the physical and chemical properties of base pair mismatches influence RNA structural stability." @default.
- W4207066160 created "2022-01-26" @default.
- W4207066160 creator A5001913548 @default.
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- W4207066160 date "2022-04-01" @default.
- W4207066160 modified "2023-10-12" @default.
- W4207066160 title "pH dependence of C•A, G•A and A•A mismatches in the stem of precursor microRNA-31" @default.
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- W4207066160 doi "https://doi.org/10.1016/j.bpc.2022.106763" @default.
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