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- W4207066192 abstract "Patients diagnosed with basal-like (also known as basal) subtype breast cancer face a more aggressive disease course and more dismal prognosis than patients diagnosed with luminal A and luminal B breast cancer molecular subtypes (1-4). We mined published microarray data (5, 6) to understand in an unbiased fashion the most distinguishing genetic and transcriptional features of tumors from patients with basal or basal-like subtype breast cancer. We identified a single nucleotide polymorphism, rs259129, residing within CMYA5, as among the most significant genetic differences in the tumors of patients with basal-like breast cancer. In a separate cohort of patients with basal subtype breast cancer, we observed transcriptome-wide differential expression of a CMYA5 transcript. Analysis of patient survival data revealed that CMYA5 primary tumor expression was correlated with recurrence-free survival in all patients save for patients with normal-like breast cancer. Sequence variation in the CMYA5 gene may be important in understanding differences in genetic background that favor development of basal subtype human breast cancer." @default.
- W4207066192 created "2022-01-26" @default.
- W4207066192 creator A5024900493 @default.
- W4207066192 date "2022-01-22" @default.
- W4207066192 modified "2023-09-24" @default.
- W4207066192 title "A single nucleotide variant on chromosome 5 residing within CMYA5 distinguishes patients with basal-like human breast cancer." @default.
- W4207066192 doi "https://doi.org/10.31219/osf.io/eztuh" @default.
- W4207066192 hasPublicationYear "2022" @default.
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