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- W4207067744 abstract "Significance Pseudouridine is among the most-abundant RNA modifications. We present a framework for conceptualizing how eukaryotic pseudouridine synthases select their substrates. This work reveals the structure of yeast pseudouridine synthase 7 (Pus7) and presents cell-based and biochemical investigations of enzyme binding and activity. We demonstrate that Pus7 interacts promiscuously with RNAs containing UG U AR sequences. Our observations raise the question of why these enzymes only modify <5% of UG U AR sequences in the transcriptome, suggesting that factors beyond inherent enzyme properties—such as protein localization, local RNA structure, and RNA–protein interactions—principally shape Pus7 substrate selection. These findings support a role for Pus7 in providing cells with a mechanism to rapidly alter protein synthesis in response to cellular conditions." @default.
- W4207067744 created "2022-01-26" @default.
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- W4207067744 date "2022-01-20" @default.
- W4207067744 modified "2023-10-12" @default.
- W4207067744 title "Pseudouridine synthase 7 is an opportunistic enzyme that binds and modifies substrates with diverse sequences and structures" @default.
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- W4207067744 doi "https://doi.org/10.1073/pnas.2109708119" @default.
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