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- W4207068215 abstract "Making CAR T cells in vivo Cardiac fibrosis is the stiffening and scarring of heart tissue and can be fatal. Rurik et al . designed an immunotherapy strategy to generate transient chimeric antigen receptor (CAR) T cells that can recognize the fibrotic cells in the heart (see the Perspective by Gao and Chen). By injecting CD5-targeted lipid nanoparticles containing the messenger RNA (mRNA) instructions needed to reprogram T lymphocytes, the researchers were able to generate therapeutic CAR T cells entirely inside the body. Analysis of a mouse model of heart disease revealed that the approach was successful in reducing fibrosis and restoring cardiac function. The ability to produce CAR T cells in vivo using modified mRNA may have a number of therapeutic applications. —PNK" @default.
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- W4207068215 date "2022-01-07" @default.
- W4207068215 modified "2023-10-16" @default.
- W4207068215 title "CAR T cells produced in vivo to treat cardiac injury" @default.
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- W4207068215 doi "https://doi.org/10.1126/science.abm0594" @default.
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