FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207068713> ?p ?o ?g. }

• W4207068713 endingPage "58" @default.
• W4207068713 startingPage "49" @default.
• W4207068713 abstract "The incidence rate of tetanus has dramatically decreased following the discovery of the tetanus vaccine. A decennial booster dose is necessary to maintain the protective antibody levels after the primary vaccination schedule. The recommendations for the tetanus booster doses in adult people living with acquired immune deficiency virus (HIV) (PLWH) is similar to those for the general population. However, the duration of protective antibodies in PLWH is unknown. The aim of this study was to determine the factors affecting the response of HIV-infected individuals to tetanus vaccine and to evaluate the role of tetanus antitoxin level in determining the timing of the booster dose. PLWH attending the Adult Vaccination Unit of Ege University Faculty of Medicine Infectious Diseases and Clinical Microbiology Department were tested for tetanus antibodies from 30 October to 30 November 2020. Demographic information and the history of primary vaccination and booster doses were derived from medical files. Tetanus antibodies were detected with enzyme immunoassay (EIA) method with Clostridium tetani toxin 5S IgG-enzyme linked immunosorbent assay (ELISA) kit (Nova Lisa, Novatec Immundiagnostica, Germany). Antibody levels <0.01 IU/ml were considered negative, 0.01-0.5 IU/ml weak positive, 0.51-1.0 IU/ml positive and > 1.1 IU/ml strong positive. A level ≥ 0.50 IU/ml was considered as protective. The study included 146 PLWH [men (n= 126) and women (n= 40)]. The mean age was 39.5 ± 11.20 years (range: 18-65). Protective antibody level was detected in 114 (78.1%) participants. Receiver operating characteristics (ROC) analysis revealed that the ideal lower limit of CD4+ T cell count during booster vaccination for a person to develop protective antibody level was calculated as ≥ 218 cell/mm3. In the multivariate analysis, it was found that age <50 years (OR= 16.4, 95% CI= 4.9-55.2), the absence of AIDS at the time of diagnosis (OR= 6.7, 95% Cl= 1.05-17.4) and CD4+ T cell count ≥ 218 cells/mm3 at the time of vaccination (OR= 4.2, 95% CI= 1.05-17.4) were associated with protective levels of antibody. Protective levels of tetanus antibodies in PLWH are lower than the general population. It should be considered that the booster dose may be required earlier, especially in PLWH who are > 50 years old, with CD4+ T lymphocyte count <200 cells/mm3 during previous booster vaccination and who had AIDS at the time of the diagnosis." @default.
• W4207068713 created "2022-01-26" @default.
• W4207068713 creator A5003509227 @default.
• W4207068713 creator A5018136575 @default.
• W4207068713 creator A5020533969 @default.
• W4207068713 creator A5021285995 @default.
• W4207068713 creator A5054049307 @default.
• W4207068713 creator A5082473228 @default.
• W4207068713 date "2022-01-21" @default.
• W4207068713 modified "2023-09-25" @default.
• W4207068713 title "HIV ile Yaşayan Bireylerde Tetanos Aşısının Rapeli Daha Erken Yapılmalı Mı?" @default.
• W4207068713 doi "https://doi.org/10.5578/mb.20229905" @default.
• W4207068713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35088959" @default.
• W4207068713 hasPublicationYear "2022" @default.
• W4207068713 type Work @default.
• W4207068713 citedByCount "0" @default.
• W4207068713 crossrefType "journal-article" @default.
• W4207068713 hasAuthorship W4207068713A5003509227 @default.
• W4207068713 hasAuthorship W4207068713A5018136575 @default.
• W4207068713 hasAuthorship W4207068713A5020533969 @default.
• W4207068713 hasAuthorship W4207068713A5021285995 @default.
• W4207068713 hasAuthorship W4207068713A5054049307 @default.
• W4207068713 hasAuthorship W4207068713A5082473228 @default.
• W4207068713 hasBestOaLocation W42070687131 @default.
• W4207068713 hasConcept C120665830 @default.
• W4207068713 hasConcept C121332964 @default.
• W4207068713 hasConcept C12590561 @default.
• W4207068713 hasConcept C126322002 @default.
• W4207068713 hasConcept C159654299 @default.
• W4207068713 hasConcept C187212893 @default.
• W4207068713 hasConcept C203014093 @default.
• W4207068713 hasConcept C22070199 @default.
• W4207068713 hasConcept C2776612079 @default.
• W4207068713 hasConcept C2779841045 @default.
• W4207068713 hasConcept C2780791431 @default.
• W4207068713 hasConcept C2780801004 @default.
• W4207068713 hasConcept C2908647359 @default.
• W4207068713 hasConcept C61511704 @default.
• W4207068713 hasConcept C71924100 @default.
• W4207068713 hasConcept C99454951 @default.
• W4207068713 hasConceptScore W4207068713C120665830 @default.
• W4207068713 hasConceptScore W4207068713C121332964 @default.
• W4207068713 hasConceptScore W4207068713C12590561 @default.
• W4207068713 hasConceptScore W4207068713C126322002 @default.
• W4207068713 hasConceptScore W4207068713C159654299 @default.
• W4207068713 hasConceptScore W4207068713C187212893 @default.
• W4207068713 hasConceptScore W4207068713C203014093 @default.
• W4207068713 hasConceptScore W4207068713C22070199 @default.
• W4207068713 hasConceptScore W4207068713C2776612079 @default.
• W4207068713 hasConceptScore W4207068713C2779841045 @default.
• W4207068713 hasConceptScore W4207068713C2780791431 @default.
• W4207068713 hasConceptScore W4207068713C2780801004 @default.
• W4207068713 hasConceptScore W4207068713C2908647359 @default.
• W4207068713 hasConceptScore W4207068713C61511704 @default.
• W4207068713 hasConceptScore W4207068713C71924100 @default.
• W4207068713 hasConceptScore W4207068713C99454951 @default.
• W4207068713 hasIssue "1" @default.
• W4207068713 hasLocation W42070687131 @default.
• W4207068713 hasLocation W42070687132 @default.
• W4207068713 hasOpenAccess W4207068713 @default.
• W4207068713 hasPrimaryLocation W42070687131 @default.
• W4207068713 hasRelatedWork W2092600119 @default.
• W4207068713 hasRelatedWork W2159238102 @default.
• W4207068713 hasRelatedWork W2354916412 @default.
• W4207068713 hasRelatedWork W2405825372 @default.
• W4207068713 hasRelatedWork W2431176454 @default.
• W4207068713 hasRelatedWork W2622413516 @default.
• W4207068713 hasRelatedWork W4207068713 @default.
• W4207068713 hasRelatedWork W4213265309 @default.
• W4207068713 hasRelatedWork W96843098 @default.
• W4207068713 hasRelatedWork W2506423265 @default.
• W4207068713 hasVolume "56" @default.
• W4207068713 isParatext "false" @default.
• W4207068713 isRetracted "false" @default.
• W4207068713 workType "article" @default.