Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207069486> ?p ?o ?g. }
- W4207069486 abstract "Autologous bone grafts are commonly used as the gold standard to repair and regenerate diseased bones. However, they are strongly associated with postoperative complications, especially at the donor site, and increased surgical costs. In an effort to overcome these limitations, tissue engineering (TE) has been proposed as an alternative to promote bone repair. The successful outcome of tissue engineering depends on the microstructure and composition of the materials used as scaffold. Decellularized bone matrix-based biomaterials have been applied as bioscaffolds in bone tissue engineering. These biomaterials play an important role in providing the mechanical and physical microenvironment needed by cells to proliferate and survive. Decellularized extracellular matrix (dECM) can be used as a powder, hydrogel and electrospun scaffolds. These bioscaffolds mimic the native microenvironment due to their structure similar to the original tissue. The aim of this review is to highlight the bone decellularization techniques. Herein we discuss: (1) bone structure; (2) properties of an ideal scaffold; (3) the potential of decellularized bone as bioscaffolds; (4) terminal sterilization of decellularized bone; (5) cell removing confirmation in decellularized tissues; and (6) post decellularization procedures. Finally, the improvement of bone formation by dECM and the immunogenicity aspect of using the decellularized bone matrix are presented, to illustrate how novel dECM-based materials can be used as bioscaffold in tissue engineering. A comprehensive understanding of tissue engineering may allow for better incorporation of therapeutic approaches in bone defects allowing for bone repair and regeneration." @default.
- W4207069486 created "2022-01-26" @default.
- W4207069486 creator A5039959042 @default.
- W4207069486 creator A5077124845 @default.
- W4207069486 creator A5082812386 @default.
- W4207069486 date "2022-01-05" @default.
- W4207069486 modified "2023-10-14" @default.
- W4207069486 title "Application of decellularized bone matrix as a bioscaffold in bone tissue engineering" @default.
- W4207069486 cites W1202406640 @default.
- W4207069486 cites W1901274024 @default.
- W4207069486 cites W1978993910 @default.
- W4207069486 cites W1987813151 @default.
- W4207069486 cites W1988170766 @default.
- W4207069486 cites W1991245603 @default.
- W4207069486 cites W2006875835 @default.
- W4207069486 cites W2009845905 @default.
- W4207069486 cites W2017209576 @default.
- W4207069486 cites W2028011772 @default.
- W4207069486 cites W2078246403 @default.
- W4207069486 cites W2128089445 @default.
- W4207069486 cites W2134972873 @default.
- W4207069486 cites W2135228592 @default.
- W4207069486 cites W2150267994 @default.
- W4207069486 cites W2296134307 @default.
- W4207069486 cites W2350984012 @default.
- W4207069486 cites W2512976060 @default.
- W4207069486 cites W2517825176 @default.
- W4207069486 cites W2553843544 @default.
- W4207069486 cites W2557975987 @default.
- W4207069486 cites W2580767461 @default.
- W4207069486 cites W2581734255 @default.
- W4207069486 cites W2592828555 @default.
- W4207069486 cites W2593643061 @default.
- W4207069486 cites W2598065748 @default.
- W4207069486 cites W2603374379 @default.
- W4207069486 cites W2609961151 @default.
- W4207069486 cites W2610537465 @default.
- W4207069486 cites W2623141522 @default.
- W4207069486 cites W2735187899 @default.
- W4207069486 cites W2735252503 @default.
- W4207069486 cites W2739954905 @default.
- W4207069486 cites W2745191008 @default.
- W4207069486 cites W2745899485 @default.
- W4207069486 cites W2752386328 @default.
- W4207069486 cites W2768626269 @default.
- W4207069486 cites W2772446760 @default.
- W4207069486 cites W2774504255 @default.
- W4207069486 cites W2778554801 @default.
- W4207069486 cites W2779551778 @default.
- W4207069486 cites W2780315214 @default.
- W4207069486 cites W2790020775 @default.
- W4207069486 cites W2796566426 @default.
- W4207069486 cites W2800301217 @default.
- W4207069486 cites W2801809123 @default.
- W4207069486 cites W280215210 @default.
- W4207069486 cites W2807291660 @default.
- W4207069486 cites W2839646944 @default.
- W4207069486 cites W2887215933 @default.
- W4207069486 cites W2887455964 @default.
- W4207069486 cites W2887607796 @default.
- W4207069486 cites W2890042145 @default.
- W4207069486 cites W2897868538 @default.
- W4207069486 cites W2898786997 @default.
- W4207069486 cites W2901194829 @default.
- W4207069486 cites W2903265597 @default.
- W4207069486 cites W2904444744 @default.
- W4207069486 cites W2906099961 @default.
- W4207069486 cites W2909240409 @default.
- W4207069486 cites W2911643782 @default.
- W4207069486 cites W291408754 @default.
- W4207069486 cites W2914788525 @default.
- W4207069486 cites W2924144567 @default.
- W4207069486 cites W2927902416 @default.
- W4207069486 cites W2934058139 @default.
- W4207069486 cites W2945226942 @default.
- W4207069486 cites W2945351481 @default.
- W4207069486 cites W2945423790 @default.
- W4207069486 cites W2948113997 @default.
- W4207069486 cites W2951014231 @default.
- W4207069486 cites W2953678388 @default.
- W4207069486 cites W2954993151 @default.
- W4207069486 cites W2955847026 @default.
- W4207069486 cites W2959527885 @default.
- W4207069486 cites W2966992518 @default.
- W4207069486 cites W2969721455 @default.
- W4207069486 cites W2971043417 @default.
- W4207069486 cites W2977306363 @default.
- W4207069486 cites W2981167732 @default.
- W4207069486 cites W2990958964 @default.
- W4207069486 cites W2991278717 @default.
- W4207069486 cites W2993219182 @default.
- W4207069486 cites W2995627111 @default.
- W4207069486 cites W2999129511 @default.
- W4207069486 cites W3007445065 @default.
- W4207069486 cites W3020379351 @default.
- W4207069486 cites W3026218051 @default.
- W4207069486 cites W3032045496 @default.
- W4207069486 cites W3036884313 @default.
- W4207069486 cites W3038015165 @default.
- W4207069486 cites W3045296238 @default.