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- W4207070390 abstract "Abstract Background The SEC61 translocon gamma subunit (SEC61G) is a component of the SEC61 complex, which import protein into the endoplasmic reticulum. However, the correlation between SEC61G and disease prognosis in head and neck squamous cell carcinoma (HNSCC) remains unclear. Methods SEC61G expression was analyzed using publicly-available datasets. The association between SEC61G and disease prognosis was evaluated. SEC61G methylation and copy number variation were investigated and gene set enrichment analysis (GSEA) and gene ontology (GO) analyses identified SEC61G-associated functions. We also investigated the correlation between SEC61G and immune cell infiltration. Finally, immunohistochemistry (IHC) was used to detect SEC61G expression in oropharyngeal carcinoma. Results SEC61G was overexpressed in pan-cancers, including HNSCC, and negatively correlated with overall survival ( p <0.001 for TCGA-HNSCC and p= 0.019 for GSE65858). Moreover, SEC61G was an independent prognostic factor for overall survival (OS) in TCGA and GSE65858 [hazard ratio (HR)=1.80, 95% CI: 1.35-2.39, p <0.001; HR＝1.87, 95% CI: 1.14-3.07, p=0.013, respectively). SEC61G DNA amplification (9.66% of patients) was significantly associated with poor OS ( p =0.034). SEC61G overexpression and DNA amplification negatively correlated with B cell, CD8 + T cell, CD4 + T cell, macrophage, neutrophil, and dendritic cell infiltration (all p <0.05). Among patients with metastatic urothelial cancer received atezolizumab, patients with high SEC61G expression had an inferior OS (p=0.006). Furthermore, SEC61G protein expression was also an independent prognostic factor of OS (HR=2.49, 95% CI: 1.15-5.30, p =0.020) and progression-free survival (HR=2.82, 95% CI: 1.36-5.84, p =0.005) for oropharyngeal cancer. Conclusions SEC61G is overexpressed in HNSCC and is an independent prognostic factor for OS. SEC61G DNA amplification contributes to overexpression and poor outcome. Interestingly, SEC61G correlates with immune cell infiltration in HNSCC. These findings suggest that SEC61G is a potential broad-spectrum biomarker for prognosis in HNSCC." @default.
- W4207070390 created "2022-01-26" @default.
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- W4207070390 date "2021-01-28" @default.
- W4207070390 modified "2023-10-18" @default.
- W4207070390 title "SEC61G Overexpression and DNA Amplification Correlates With Prognosis and Immune Cell Infiltration in Head and Neck Squamous Cell Carcinoma" @default.
- W4207070390 doi "https://doi.org/10.21203/rs.3.rs-153933/v1" @default.
- W4207070390 hasPublicationYear "2021" @default.
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