FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207071566> ?p ?o ?g. }

• W4207071566 abstract "Background: Eosinophilic chronic sinusitis (ECRS) is a subtype of CRS with nasal polyps (CRSwNP) that is frequently comorbid with asthma. Notably, ECRS patients often show a high recurrence of NPs after surgical resection. Leptin is a hormone produced by adipocytes that has been implicated in airway inflammatory diseases. However, to date, the role of leptin in ECRS has not been investigated. Objective: To determine whether the serum levels of leptin are altered in patients with ECRS. Methods: In total, 40 patients with ECRS, 15 patients with non-eosinophilic CRS (non-ECRS), and 12 individuals without CRS (control) were included in this study. Patient's serum leptin levels were assessed, and the number of eosinophils in their NPs were measured through a histological evaluation of the three densest areas with cellular infiltrate beneath the epithelial surface. Finally, nasal fibroblast cultures established from NPs were stimulated with varying concentrations of recombinant leptin in vitro to determine whether leptin affects eotaxin-3 (Chemokine (C-C motif) ligand 26 :26: CCL26) expression. Results: The serum leptin levels in both the ECRS and non-ECRS groups were significantly higher than those in the control subjects (p < 0.0001 vs. ECRS; p < 0.05 vs. non-ECRS). Furthermore, ECRS patients displayed significantly elevated serum leptin levels compared to non-ECRS patients (p < 0.001), although there was no difference in body mass index between the groups. Notably, serum leptin levels were correlated with the proportion of eosinophils in peripheral blood (r = 0.3575, p < 0.01) and the number of eosinophils in NPs (r = 0.5109, p < 0.0001). Serum leptin levels were also correlated with eotaxin-3 mRNA expression in NPs (r = 0.5374, p < 0.01). Finally, leptin significantly augmented eotaxin-3 expression in nasal fibroblasts established in vitro from NPs in a leptin receptor-dependent manner (p < 0.05). Conclusion: Leptin levels are elevated in ECRS patients and may both promote and indicate the severity of ECRS as well as systemic type 2-biased inflammatory responses. Combined, these data indicate that circulating leptin may play a significant role in the development of eosinophilic inflammation in NPs." @default.
• W4207071566 created "2022-01-26" @default.
• W4207071566 creator A5003256422 @default.
• W4207071566 creator A5004735837 @default.
• W4207071566 creator A5023688006 @default.
• W4207071566 creator A5026036503 @default.
• W4207071566 creator A5033982558 @default.
• W4207071566 creator A5036218575 @default.
• W4207071566 creator A5036423798 @default.
• W4207071566 creator A5044798660 @default.
• W4207071566 creator A5050909345 @default.
• W4207071566 creator A5056666751 @default.
• W4207071566 creator A5057446753 @default.
• W4207071566 creator A5059537540 @default.
• W4207071566 creator A5061990193 @default.
• W4207071566 creator A5068428818 @default.
• W4207071566 creator A5069240767 @default.
• W4207071566 creator A5070585553 @default.
• W4207071566 creator A5091374418 @default.
• W4207071566 date "2022-01-03" @default.
• W4207071566 modified "2023-10-18" @default.
• W4207071566 title "Elevated Serum Leptin Levels in Patients With Eosinophilic Chronic Rhinosinusitis" @default.
• W4207071566 cites W1551216731 @default.
• W4207071566 cites W1597838084 @default.
• W4207071566 cites W1885435857 @default.
• W4207071566 cites W1941195165 @default.
• W4207071566 cites W1964913727 @default.
• W4207071566 cites W1967942432 @default.
• W4207071566 cites W1968623293 @default.
• W4207071566 cites W1970354614 @default.
• W4207071566 cites W1985121334 @default.
• W4207071566 cites W1985475058 @default.
• W4207071566 cites W1989016600 @default.
• W4207071566 cites W1999233686 @default.
• W4207071566 cites W2008112483 @default.
• W4207071566 cites W2015130768 @default.
• W4207071566 cites W2017485218 @default.
• W4207071566 cites W2028435922 @default.
• W4207071566 cites W2034839341 @default.
• W4207071566 cites W2036867429 @default.
• W4207071566 cites W2041267049 @default.
• W4207071566 cites W2051338201 @default.
• W4207071566 cites W2052137119 @default.
• W4207071566 cites W2061376514 @default.
• W4207071566 cites W2061944578 @default.
• W4207071566 cites W2062113393 @default.
• W4207071566 cites W2064119981 @default.
• W4207071566 cites W2068507937 @default.
• W4207071566 cites W2074897148 @default.
• W4207071566 cites W2081748056 @default.
• W4207071566 cites W2101921785 @default.
• W4207071566 cites W2112693061 @default.
• W4207071566 cites W2120758015 @default.
• W4207071566 cites W2124913216 @default.
• W4207071566 cites W2129761445 @default.
• W4207071566 cites W2132919605 @default.
• W4207071566 cites W2138355864 @default.
• W4207071566 cites W2142435309 @default.
• W4207071566 cites W2142554389 @default.
• W4207071566 cites W2151079173 @default.
• W4207071566 cites W2151258015 @default.
• W4207071566 cites W2151379408 @default.
• W4207071566 cites W2151987208 @default.
• W4207071566 cites W2152442915 @default.
• W4207071566 cites W2160103886 @default.
• W4207071566 cites W2208093466 @default.
• W4207071566 cites W2275028388 @default.
• W4207071566 cites W2289316671 @default.
• W4207071566 cites W2313139832 @default.
• W4207071566 cites W2324417905 @default.
• W4207071566 cites W2470163504 @default.
• W4207071566 cites W2507865182 @default.
• W4207071566 cites W2517035143 @default.
• W4207071566 cites W2519161146 @default.
• W4207071566 cites W2567558689 @default.
• W4207071566 cites W2604291894 @default.
• W4207071566 cites W2611413896 @default.
• W4207071566 cites W2725965589 @default.
• W4207071566 cites W2807414321 @default.
• W4207071566 cites W2895776519 @default.
• W4207071566 cites W2902881383 @default.
• W4207071566 cites W2913617956 @default.
• W4207071566 cites W2973437633 @default.
• W4207071566 cites W2976615491 @default.
• W4207071566 cites W2998354760 @default.
• W4207071566 cites W3005931313 @default.
• W4207071566 cites W3142400946 @default.
• W4207071566 cites W3165178936 @default.
• W4207071566 doi "https://doi.org/10.3389/fphar.2021.793607" @default.
• W4207071566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35046816" @default.
• W4207071566 hasPublicationYear "2022" @default.
• W4207071566 type Work @default.
• W4207071566 citedByCount "5" @default.
• W4207071566 countsByYear W42070715662022 @default.
• W4207071566 countsByYear W42070715662023 @default.
• W4207071566 crossrefType "journal-article" @default.
• W4207071566 hasAuthorship W4207071566A5003256422 @default.
• W4207071566 hasAuthorship W4207071566A5004735837 @default.
• W4207071566 hasAuthorship W4207071566A5023688006 @default.
• W4207071566 hasAuthorship W4207071566A5026036503 @default.

• next