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• W4207074254 abstract "Although both diet-induced obesity and psychological stress are recognized as significant independent contributors to cardiometabolic and behavioral disorders, our understanding of how these two disorders interact and influence cardiometabolic risk and myocardial ischemic tolerance is limited. The aim of this study was to assess the combined effects of an obesogenic diet and psychological stress on cardiometabolic risk factors (body weight, dyslipidemia, insulin sensitivity) and postischemic cardiovascular outcomes. C57Bl/6J mice (n = 48) were subject to a combination of 22 weeks of western diet (WD) feeding and chronic restraint stress (CRS) for the last 4 weeks. Metabolic and behavioral changes were assessed using glucose tolerance tests and open field tests (OFTs), respectively. After 22 weeks, cardiac function and ischemic tolerance were assessed in Langendorff perfused hearts. WD feeding increased body weight and worsened blood lipids and insulin sensitivity. WD-fed mice also exhibited reduced exploratory behavior within the OFT. CRS reduced body weight and increased locomotion in both dietary groups and had differential effects on fasting glucose metabolism in the two dietary groups while not impacting non-fasting insulin. Although the WD only marginally reduced reperfusion left ventricular developed pressure recovery, CRS worsened reperfusion diastolic dysfunction in both dietary groups. Interestingly, despite WD+CRS animals exhibiting improved cardiometabolic parameters compared to the WD group, these changes did not translate to marked improvements to postischemic cardiac outcomes. In conclusion, in this study, combined WD feeding and CRS did not act synergistically to worsen cardiometabolic risk factors but instead improved them. Despite these cardiometabolic improvements, WD+CRS increased reperfusion end diastolic pressure which may be indicative of worsened ischemia/reperfusion injury." @default.
• W4207074254 created "2022-01-26" @default.
• W4207074254 creator A5000794213 @default.
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• W4207074254 creator A5080289942 @default.
• W4207074254 creator A5087699122 @default.
• W4207074254 date "2022-01-01" @default.
• W4207074254 modified "2023-09-26" @default.
• W4207074254 title "Stress‐induced body weight loss and improvements in cardiometabolic risk factors do not translate to improved myocardial ischemic tolerance in western diet‐fed mice" @default.
• W4207074254 cites W1506176296 @default.
• W4207074254 cites W1724398224 @default.
• W4207074254 cites W175842496 @default.
• W4207074254 cites W1903501615 @default.
• W4207074254 cites W1930763255 @default.
• W4207074254 cites W1966037459 @default.
• W4207074254 cites W1971117072 @default.
• W4207074254 cites W1983355200 @default.
• W4207074254 cites W1987491785 @default.
• W4207074254 cites W1994862644 @default.
• W4207074254 cites W1998234914 @default.
• W4207074254 cites W2001417587 @default.
• W4207074254 cites W2002451527 @default.
• W4207074254 cites W2003070777 @default.
• W4207074254 cites W2003903023 @default.
• W4207074254 cites W2005347628 @default.
• W4207074254 cites W2007697890 @default.
• W4207074254 cites W2019446944 @default.
• W4207074254 cites W2021385892 @default.
• W4207074254 cites W2024204801 @default.
• W4207074254 cites W2031262386 @default.
• W4207074254 cites W2034355214 @default.
• W4207074254 cites W2034538279 @default.
• W4207074254 cites W2046153056 @default.
• W4207074254 cites W2050270810 @default.
• W4207074254 cites W2050767863 @default.
• W4207074254 cites W2051369986 @default.
• W4207074254 cites W2055034967 @default.
• W4207074254 cites W2056973638 @default.
• W4207074254 cites W2060534394 @default.
• W4207074254 cites W2060908340 @default.
• W4207074254 cites W2066918016 @default.
• W4207074254 cites W2075640203 @default.
• W4207074254 cites W2078978154 @default.
• W4207074254 cites W2090779400 @default.
• W4207074254 cites W2091993766 @default.
• W4207074254 cites W2096568900 @default.
• W4207074254 cites W2103690977 @default.
• W4207074254 cites W2113167245 @default.
• W4207074254 cites W2115167377 @default.
• W4207074254 cites W2115262069 @default.
• W4207074254 cites W2123897274 @default.
• W4207074254 cites W2129448542 @default.
• W4207074254 cites W2136638803 @default.
• W4207074254 cites W2138201763 @default.
• W4207074254 cites W2140275529 @default.
• W4207074254 cites W2143043880 @default.
• W4207074254 cites W2149099231 @default.
• W4207074254 cites W2160538599 @default.
• W4207074254 cites W2252781244 @default.
• W4207074254 cites W2285665264 @default.
• W4207074254 cites W2319981027 @default.
• W4207074254 cites W2334026052 @default.
• W4207074254 cites W2369595387 @default.
• W4207074254 cites W2474101860 @default.
• W4207074254 cites W2506904562 @default.
• W4207074254 cites W2515343123 @default.
• W4207074254 cites W2517479041 @default.
• W4207074254 cites W2590747152 @default.
• W4207074254 cites W2594074262 @default.
• W4207074254 cites W2606592708 @default.
• W4207074254 cites W2611285972 @default.
• W4207074254 cites W2620406790 @default.
• W4207074254 cites W2724362371 @default.
• W4207074254 cites W2765953779 @default.
• W4207074254 cites W2797222068 @default.
• W4207074254 cites W2801019536 @default.
• W4207074254 cites W2805171497 @default.
• W4207074254 cites W2898839513 @default.
• W4207074254 cites W2905025586 @default.
• W4207074254 cites W2913443032 @default.
• W4207074254 cites W2923535861 @default.
• W4207074254 cites W2948375763 @default.
• W4207074254 cites W2969675319 @default.
• W4207074254 cites W2972034054 @default.
• W4207074254 cites W3047426295 @default.
• W4207074254 cites W3118464238 @default.
• W4207074254 cites W3163174018 @default.
• W4207074254 cites W61976542 @default.
• W4207074254 cites W852279223 @default.
• W4207074254 doi "https://doi.org/10.14814/phy2.15170" @default.
• W4207074254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35076176" @default.
• W4207074254 hasPublicationYear "2022" @default.
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