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• W4207074338 endingPage "738" @default.
• W4207074338 startingPage "708" @default.
• W4207074338 abstract "Lysosomal peptidases are hydrolytic enzymes capable of digesting waste proteins that are targeted to lysosomes via endocytosis and autophagy. Besides intracellular protein catabolism, they play more specific roles in several other cellular processes and pathologies, either within lysosomes, upon secretion into the cell cytoplasm or extracellular space, or bound to the plasma membrane. In cancer, lysosomal peptidases are generally associated with disease progression, as they participate in crucial processes leading to changes in cell morphology, signaling, migration, and invasion, and finally metastasis. However, they can also enhance the mechanisms resulting in cancer regression, such as apoptosis of tumor cells or antitumor immune responses. Lysosomal peptidases have also been identified as hallmarks of aging and neurodegeneration, playing roles in oxidative stress, mitochondrial dysfunction, abnormal intercellular communication, dysregulated trafficking, and the deposition of protein aggregates in neuronal cells. Furthermore, deficiencies in lysosomal peptidases may result in other pathological states, such as lysosomal storage disease. The aim of this review was to highlight the role of lysosomal peptidases in particular pathological processes of cancer and neurodegeneration and to address the potential of lysosomal peptidases in diagnosing and treating patients." @default.
• W4207074338 created "2022-01-26" @default.
• W4207074338 creator A5007520912 @default.
• W4207074338 creator A5059675124 @default.
• W4207074338 creator A5071460704 @default.
• W4207074338 creator A5081384764 @default.
• W4207074338 date "2022-02-03" @default.
• W4207074338 modified "2023-10-18" @default.
• W4207074338 title "Lysosomal peptidases—intriguing roles in cancer progression and neurodegeneration" @default.
• W4207074338 cites W1133270011 @default.
• W4207074338 cites W1197219833 @default.
• W4207074338 cites W1483408272 @default.
• W4207074338 cites W1488972347 @default.
• W4207074338 cites W149130878 @default.
• W4207074338 cites W1492028205 @default.
• W4207074338 cites W1516464304 @default.
• W4207074338 cites W1518043112 @default.
• W4207074338 cites W1550463937 @default.
• W4207074338 cites W1552611029 @default.
• W4207074338 cites W1572389123 @default.
• W4207074338 cites W1581527620 @default.
• W4207074338 cites W1611493548 @default.
• W4207074338 cites W1627140218 @default.
• W4207074338 cites W166433058 @default.
• W4207074338 cites W1680217275 @default.
• W4207074338 cites W1754345123 @default.
• W4207074338 cites W18034176 @default.
• W4207074338 cites W1823586356 @default.
• W4207074338 cites W1828517887 @default.
• W4207074338 cites W1845792010 @default.
• W4207074338 cites W1852264095 @default.
• W4207074338 cites W1859269419 @default.
• W4207074338 cites W1862255621 @default.
• W4207074338 cites W1870060349 @default.
• W4207074338 cites W1894006267 @default.
• W4207074338 cites W1907174433 @default.
• W4207074338 cites W1914000625 @default.
• W4207074338 cites W1923386801 @default.
• W4207074338 cites W1940237119 @default.
• W4207074338 cites W1953569376 @default.
• W4207074338 cites W1960543132 @default.
• W4207074338 cites W1964962472 @default.
• W4207074338 cites W1965696202 @default.
• W4207074338 cites W1967035072 @default.
• W4207074338 cites W1969254696 @default.
• W4207074338 cites W1969554577 @default.
• W4207074338 cites W1972840765 @default.
• W4207074338 cites W1973373558 @default.
• W4207074338 cites W1973573196 @default.
• W4207074338 cites W1973703293 @default.
• W4207074338 cites W1974250737 @default.
• W4207074338 cites W1975139823 @default.
• W4207074338 cites W1975553195 @default.
• W4207074338 cites W1975883081 @default.
• W4207074338 cites W1977623581 @default.
• W4207074338 cites W1978527995 @default.
• W4207074338 cites W1979635499 @default.
• W4207074338 cites W1979948510 @default.
• W4207074338 cites W1980792888 @default.
• W4207074338 cites W1981225291 @default.
• W4207074338 cites W1981812290 @default.
• W4207074338 cites W1981912331 @default.
• W4207074338 cites W1983752276 @default.
• W4207074338 cites W1984073321 @default.
• W4207074338 cites W1985619086 @default.
• W4207074338 cites W1987166518 @default.
• W4207074338 cites W1988022242 @default.
• W4207074338 cites W1988494097 @default.
• W4207074338 cites W1989756817 @default.
• W4207074338 cites W1990273557 @default.
• W4207074338 cites W1990328562 @default.
• W4207074338 cites W1990494772 @default.
• W4207074338 cites W1992359809 @default.
• W4207074338 cites W1993442154 @default.
• W4207074338 cites W1993714499 @default.
• W4207074338 cites W1994185878 @default.
• W4207074338 cites W1994263020 @default.
• W4207074338 cites W1994519378 @default.
• W4207074338 cites W1996024251 @default.
• W4207074338 cites W1997299718 @default.
• W4207074338 cites W1997454513 @default.
• W4207074338 cites W1997484584 @default.
• W4207074338 cites W1997541914 @default.
• W4207074338 cites W1998750669 @default.
• W4207074338 cites W1998788716 @default.
• W4207074338 cites W2000482990 @default.
• W4207074338 cites W2000580759 @default.
• W4207074338 cites W2000799034 @default.
• W4207074338 cites W2001621817 @default.
• W4207074338 cites W2002113371 @default.
• W4207074338 cites W2004932952 @default.
• W4207074338 cites W2006193439 @default.
• W4207074338 cites W2008577620 @default.
• W4207074338 cites W2009246830 @default.
• W4207074338 cites W2010912389 @default.
• W4207074338 cites W2012033013 @default.
• W4207074338 cites W2012066550 @default.
• W4207074338 cites W2014448533 @default.

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