Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207075771> ?p ?o ?g. }
- W4207075771 abstract "Allogeneic haematopoietic stem cell transplantation (HSCT) is indicated in children with high-risk, relapsed or refractory acute lymphoblastic leukaemia (ALL). HLA-matched grafts from cord blood and stem cell repositories have allowed patients without suitable sibling donors to undergo HSCT. However, challenges in procuring matched unrelated donor (MUD) grafts due to high cost, ethnic disparity and time constraints have led to the exponential rise in the use of stem cells from human leukocyte antigen (HLA)-haploidentical family donors. Whilst HLA-haploidentical HSCT (hHSCT) performed in adult patients with acute leukaemia has produced outcomes similar to MUD transplants, experience in children is limited. Over the last 5 years, more data have emerged on hHSCT in the childhood ALL setting, allowing comparisons with matched donor transplants. The feasibility of hHSCT using adult family donors in childhood ALL may also address the ethical issues related to selection of minor siblings in matched sibling donor transplants. Here, we review hHSCT in paediatric recipients with ALL and highlight the emergence of hHSCT as a promising therapeutic option for patients lacking a suitable matched donor. Recent issues related to conditioning regimens, donor selection and graft-vs.-host disease prophylaxis are discussed. We also identify areas for future research to address transplant-related complications and improve post-transplant disease-free survival." @default.
- W4207075771 created "2022-01-26" @default.
- W4207075771 creator A5006767169 @default.
- W4207075771 creator A5012528149 @default.
- W4207075771 creator A5026441854 @default.
- W4207075771 creator A5027687456 @default.
- W4207075771 date "2022-01-21" @default.
- W4207075771 modified "2023-10-14" @default.
- W4207075771 title "HLA-Haploidentical Family Donors: The New Promise for Childhood Acute Lymphoblastic Leukaemia?" @default.
- W4207075771 cites W1444277189 @default.
- W4207075771 cites W1500207187 @default.
- W4207075771 cites W1978032636 @default.
- W4207075771 cites W1981690705 @default.
- W4207075771 cites W1982023850 @default.
- W4207075771 cites W1982870281 @default.
- W4207075771 cites W1985032453 @default.
- W4207075771 cites W1986741896 @default.
- W4207075771 cites W1989966599 @default.
- W4207075771 cites W1993072586 @default.
- W4207075771 cites W1994848278 @default.
- W4207075771 cites W1996697756 @default.
- W4207075771 cites W2003399339 @default.
- W4207075771 cites W2005713671 @default.
- W4207075771 cites W2009382439 @default.
- W4207075771 cites W2029070864 @default.
- W4207075771 cites W2039334806 @default.
- W4207075771 cites W2046689400 @default.
- W4207075771 cites W2048452843 @default.
- W4207075771 cites W2060578002 @default.
- W4207075771 cites W2061878111 @default.
- W4207075771 cites W2072290737 @default.
- W4207075771 cites W2085960733 @default.
- W4207075771 cites W2089170575 @default.
- W4207075771 cites W2093107492 @default.
- W4207075771 cites W2107334994 @default.
- W4207075771 cites W2122465970 @default.
- W4207075771 cites W2130663466 @default.
- W4207075771 cites W2139865910 @default.
- W4207075771 cites W2145727904 @default.
- W4207075771 cites W2163309297 @default.
- W4207075771 cites W2204458889 @default.
- W4207075771 cites W2215252198 @default.
- W4207075771 cites W2252670258 @default.
- W4207075771 cites W2302206374 @default.
- W4207075771 cites W2306523345 @default.
- W4207075771 cites W2410223173 @default.
- W4207075771 cites W2416050694 @default.
- W4207075771 cites W2419026420 @default.
- W4207075771 cites W2424740985 @default.
- W4207075771 cites W2470962469 @default.
- W4207075771 cites W2527934213 @default.
- W4207075771 cites W2529331955 @default.
- W4207075771 cites W2529640136 @default.
- W4207075771 cites W2555219573 @default.
- W4207075771 cites W2593004792 @default.
- W4207075771 cites W2594747812 @default.
- W4207075771 cites W2604176819 @default.
- W4207075771 cites W2606654718 @default.
- W4207075771 cites W2608365863 @default.
- W4207075771 cites W2621546725 @default.
- W4207075771 cites W2762894618 @default.
- W4207075771 cites W2763653175 @default.
- W4207075771 cites W2764335030 @default.
- W4207075771 cites W2769990542 @default.
- W4207075771 cites W2774014792 @default.
- W4207075771 cites W2781709504 @default.
- W4207075771 cites W2786059331 @default.
- W4207075771 cites W2787765269 @default.
- W4207075771 cites W2788578140 @default.
- W4207075771 cites W2791022061 @default.
- W4207075771 cites W2793649743 @default.
- W4207075771 cites W2800550514 @default.
- W4207075771 cites W2801395676 @default.
- W4207075771 cites W2854131005 @default.
- W4207075771 cites W2895969530 @default.
- W4207075771 cites W2905059816 @default.
- W4207075771 cites W2911504656 @default.
- W4207075771 cites W2919180304 @default.
- W4207075771 cites W2945737077 @default.
- W4207075771 cites W2962839079 @default.
- W4207075771 cites W2963505883 @default.
- W4207075771 cites W2967234874 @default.
- W4207075771 cites W2972226667 @default.
- W4207075771 cites W2980837709 @default.
- W4207075771 cites W2984229323 @default.
- W4207075771 cites W2989797048 @default.
- W4207075771 cites W3006032832 @default.
- W4207075771 cites W3006512787 @default.
- W4207075771 cites W3007680074 @default.
- W4207075771 cites W3030234447 @default.
- W4207075771 cites W3031429653 @default.
- W4207075771 cites W3033972398 @default.
- W4207075771 cites W3035266621 @default.
- W4207075771 cites W3039312895 @default.
- W4207075771 cites W3043472496 @default.
- W4207075771 cites W3047469812 @default.
- W4207075771 cites W3048374264 @default.
- W4207075771 cites W3050291427 @default.
- W4207075771 cites W3054539141 @default.
- W4207075771 cites W3089322837 @default.