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- W4207076145 abstract "Patterns of genetic variation and covariation impact the evolution of the craniofacial complex and contribute to clinically significant malocclusions in modern human populations. Previous quantitative genetic studies have estimated the heritabilities and genetic correlations of skeletal and dental traits in humans and nonhuman primates, but none have estimated these quantitative genetic parameters across the dentognathic complex. A large and powerful pedigree from the Jirel population of Nepal was leveraged to estimate heritabilities and genetic correlations in 62 maxillary and mandibular arch dimensions, incisor and canine lengths, and post-canine tooth crown areas (N ≥ 739). Quantitative genetic parameter estimation was performed using maximum likelihood-based variance decomposition. Residual heritability estimates were significant for all traits, ranging from 0.269 to 0.898. Genetic correlations were positive for all trait pairs. Principal components analyses of the phenotypic and genetic correlation matrices indicate an overall size effect across all measurements on the first principal component. Additional principal components demonstrate positive relationships between post-canine tooth crown areas and arch lengths and negative relationships between post-canine tooth crown areas and arch widths, and between arch lengths and arch widths. Based on these findings, morphological variation in the human dentognathic complex may be constrained by genetic relationships between dental dimensions and arch lengths, with weaker genetic correlations between these traits and arch widths allowing for variation in arch shape. The patterns identified are expected to have impacted the evolution of the dentognathic complex and its genetic architecture as well as the prevalence of dental crowding in modern human populations." @default.
- W4207076145 created "2022-01-26" @default.
- W4207076145 creator A5001183621 @default.
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- W4207076145 creator A5032955622 @default.
- W4207076145 date "2022-01-11" @default.
- W4207076145 modified "2023-10-16" @default.
- W4207076145 title "Genetic influences on dentognathic morphology in the Jirel population of Nepal" @default.
- W4207076145 cites W1528404140 @default.
- W4207076145 cites W1543255520 @default.
- W4207076145 cites W1565964788 @default.
- W4207076145 cites W1574695045 @default.
- W4207076145 cites W1963703713 @default.
- W4207076145 cites W1964279730 @default.
- W4207076145 cites W1975417249 @default.
- W4207076145 cites W1982509277 @default.
- W4207076145 cites W1983530144 @default.
- W4207076145 cites W1986290912 @default.
- W4207076145 cites W1986543487 @default.
- W4207076145 cites W1991154569 @default.
- W4207076145 cites W1991689942 @default.
- W4207076145 cites W1996278254 @default.
- W4207076145 cites W1998137763 @default.
- W4207076145 cites W1998875247 @default.
- W4207076145 cites W2001604856 @default.
- W4207076145 cites W2002066188 @default.
- W4207076145 cites W2012344824 @default.
- W4207076145 cites W2016749392 @default.
- W4207076145 cites W2017340713 @default.
- W4207076145 cites W2017525393 @default.
- W4207076145 cites W2018092590 @default.
- W4207076145 cites W2019568293 @default.
- W4207076145 cites W2022730625 @default.
- W4207076145 cites W2022989573 @default.
- W4207076145 cites W2025806788 @default.
- W4207076145 cites W2026691765 @default.
- W4207076145 cites W2027094109 @default.
- W4207076145 cites W2027226179 @default.
- W4207076145 cites W2028375140 @default.
- W4207076145 cites W2029069149 @default.
- W4207076145 cites W2034516856 @default.
- W4207076145 cites W2038994214 @default.
- W4207076145 cites W2040847935 @default.
- W4207076145 cites W2040870478 @default.
- W4207076145 cites W2041331913 @default.
- W4207076145 cites W2042853352 @default.
- W4207076145 cites W2044144087 @default.
- W4207076145 cites W2050164743 @default.
- W4207076145 cites W2050641883 @default.
- W4207076145 cites W2051124270 @default.
- W4207076145 cites W2054152166 @default.
- W4207076145 cites W2065295496 @default.
- W4207076145 cites W2067375735 @default.
- W4207076145 cites W2070504997 @default.
- W4207076145 cites W2070802948 @default.
- W4207076145 cites W2072650676 @default.
- W4207076145 cites W2077678742 @default.
- W4207076145 cites W2083022855 @default.
- W4207076145 cites W2083487819 @default.
- W4207076145 cites W2086132793 @default.
- W4207076145 cites W2089200216 @default.
- W4207076145 cites W2092942426 @default.
- W4207076145 cites W2093064905 @default.
- W4207076145 cites W2096171798 @default.
- W4207076145 cites W2097586689 @default.
- W4207076145 cites W2104785772 @default.
- W4207076145 cites W2104923673 @default.
- W4207076145 cites W2108703000 @default.
- W4207076145 cites W2108726522 @default.
- W4207076145 cites W2109441214 @default.
- W4207076145 cites W2112507082 @default.
- W4207076145 cites W2113146951 @default.
- W4207076145 cites W2115335486 @default.
- W4207076145 cites W2116273370 @default.
- W4207076145 cites W2119443320 @default.
- W4207076145 cites W2122078922 @default.
- W4207076145 cites W2125932576 @default.
- W4207076145 cites W2126626234 @default.
- W4207076145 cites W2128051706 @default.
- W4207076145 cites W2129686683 @default.
- W4207076145 cites W2132036577 @default.
- W4207076145 cites W2133780909 @default.
- W4207076145 cites W2133866716 @default.
- W4207076145 cites W2138835205 @default.
- W4207076145 cites W2140445750 @default.
- W4207076145 cites W2140833120 @default.
- W4207076145 cites W2142853106 @default.
- W4207076145 cites W2153233501 @default.
- W4207076145 cites W2162927543 @default.
- W4207076145 cites W2165724218 @default.
- W4207076145 cites W2168686329 @default.
- W4207076145 cites W2169350146 @default.
- W4207076145 cites W2171183343 @default.
- W4207076145 cites W2282420552 @default.