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- W4207076211 endingPage "54" @default.
- W4207076211 startingPage "54" @default.
- W4207076211 abstract "Companion animals with naturally occurring cancers can provide an advantageous model for cancer research and in particular anticancer drug development. Compared to commonly utilized mouse models, companion animals, specifically dogs and cats, share a closer phylogenetical distance, body size, and genome organization. Most importantly, pets develop spontaneous, rather than artificially induced, cancers. The incidence of cancer in people and companion animals is quite similar and cancer is the leading cause of death in dogs over 10 years of age. Many cancer types in dogs and cats have similar pathological, molecular, and clinical features to their human counterparts. Drug toxicity and response to anti-cancer treatment in dogs and cats are also similar to those in people. Companion animals share their lives with their owners, including the environmental and socioeconomic cancer-risk factors. In contrast to humans, pets have a shorter life span and cancer progression is often more rapid. Clinical trials in companion animals are cheaper and less time consuming compared to human trials. Dogs and cats with naturally occurring cancers are an ideal and unique model for human cancer research. Model selection for the specific type of cancer is of pivotal importance. Although companion animal models for translational research have been reviewed previously, this review will try to summarize the most important advantages and disadvantages of this model. Feline oral squamous cell carcinoma as a model for head and neck squamous cell carcinoma and canine oral melanoma as a model for mucosal melanoma and immunotherapy in people will be discussed as examples." @default.
- W4207076211 created "2022-01-26" @default.
- W4207076211 creator A5047573360 @default.
- W4207076211 date "2021-12-31" @default.
- W4207076211 modified "2023-10-07" @default.
- W4207076211 title "Companion Animal Model in Translational Oncology; Feline Oral Squamous Cell Carcinoma and Canine Oral Melanoma" @default.
- W4207076211 cites W1519097368 @default.
- W4207076211 cites W1571153791 @default.
- W4207076211 cites W1683085693 @default.
- W4207076211 cites W1752872128 @default.
- W4207076211 cites W1919861831 @default.
- W4207076211 cites W1955438485 @default.
- W4207076211 cites W1964907920 @default.
- W4207076211 cites W1969093307 @default.
- W4207076211 cites W1969867229 @default.
- W4207076211 cites W1974451038 @default.
- W4207076211 cites W1984372402 @default.
- W4207076211 cites W1986380360 @default.
- W4207076211 cites W1995399277 @default.
- W4207076211 cites W1999140776 @default.
- W4207076211 cites W2003366192 @default.
- W4207076211 cites W2009564157 @default.
- W4207076211 cites W2014546243 @default.
- W4207076211 cites W2014931987 @default.
- W4207076211 cites W2023568503 @default.
- W4207076211 cites W2027577699 @default.
- W4207076211 cites W2028744929 @default.
- W4207076211 cites W2029253199 @default.
- W4207076211 cites W2029437176 @default.
- W4207076211 cites W2030603031 @default.
- W4207076211 cites W2042315085 @default.
- W4207076211 cites W2046626103 @default.
- W4207076211 cites W2051161636 @default.
- W4207076211 cites W2055773606 @default.
- W4207076211 cites W2056475871 @default.
- W4207076211 cites W2058185747 @default.
- W4207076211 cites W2061644933 @default.
- W4207076211 cites W2062398277 @default.
- W4207076211 cites W2063738519 @default.
- W4207076211 cites W2064009495 @default.
- W4207076211 cites W2064349256 @default.
- W4207076211 cites W2068325418 @default.
- W4207076211 cites W2070345825 @default.
- W4207076211 cites W2071263262 @default.
- W4207076211 cites W2073245859 @default.
- W4207076211 cites W2083890747 @default.
- W4207076211 cites W2098167740 @default.
- W4207076211 cites W2098264288 @default.
- W4207076211 cites W2099471033 @default.
- W4207076211 cites W2100626742 @default.
- W4207076211 cites W2103048323 @default.
- W4207076211 cites W2103752548 @default.
- W4207076211 cites W2105303945 @default.
- W4207076211 cites W2105589914 @default.
- W4207076211 cites W2110852884 @default.
- W4207076211 cites W2112766682 @default.
- W4207076211 cites W2112845420 @default.
- W4207076211 cites W2114611642 @default.
- W4207076211 cites W2114657480 @default.
- W4207076211 cites W2116089582 @default.
- W4207076211 cites W2117355140 @default.
- W4207076211 cites W2119032282 @default.
- W4207076211 cites W2121681121 @default.
- W4207076211 cites W2123694113 @default.
- W4207076211 cites W2124548256 @default.
- W4207076211 cites W2130185552 @default.
- W4207076211 cites W2141319119 @default.
- W4207076211 cites W2142492400 @default.
- W4207076211 cites W2146812359 @default.
- W4207076211 cites W2147233186 @default.
- W4207076211 cites W2149678643 @default.
- W4207076211 cites W2151351958 @default.
- W4207076211 cites W2156266404 @default.
- W4207076211 cites W2156801000 @default.
- W4207076211 cites W2165516169 @default.
- W4207076211 cites W2166502910 @default.
- W4207076211 cites W2166723305 @default.
- W4207076211 cites W2167500143 @default.
- W4207076211 cites W2167716768 @default.
- W4207076211 cites W2171203710 @default.
- W4207076211 cites W2175881750 @default.
- W4207076211 cites W2178511676 @default.
- W4207076211 cites W2185075416 @default.
- W4207076211 cites W2215259512 @default.
- W4207076211 cites W2235688937 @default.
- W4207076211 cites W2248953844 @default.
- W4207076211 cites W2253924583 @default.
- W4207076211 cites W2306535196 @default.
- W4207076211 cites W2328995829 @default.
- W4207076211 cites W2409903121 @default.
- W4207076211 cites W2442789801 @default.
- W4207076211 cites W2469610249 @default.
- W4207076211 cites W2508560490 @default.
- W4207076211 cites W2519354719 @default.
- W4207076211 cites W2578855753 @default.
- W4207076211 cites W2732743010 @default.
- W4207076211 cites W2770019418 @default.
- W4207076211 cites W2790657166 @default.