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- W4207076316 abstract "A-type botulinum toxin blocks presynaptic production of acetylcholine, thereby disrupting neuromuscular transmission, and leading to flaccid muscle paresis. Injection of toxin into the internal anal sphincter is a new, minimally invasive, effective method of treating children with hypertonicity / achalasia of the sphincter, pelvic muscle dyssynergia, stool retention, secondary fecal incontinence from rectal overflow. The effect of A-type botulinum toxin on smooth muscles of hollow organs has not been yet studied. Objective. To analyze the effect of A-type botulinum toxin on the tone of the smooth muscles of the colon in the experiment. Material and methods. The scientists examined 15 laboratory Sprague Dawley rats. The effect of A-type botulinum toxin on the tone of the smooth muscles of the large intestine was assessed by measuring the stress of the intestinal wall and intraluminal pressure. Results. The scientists revealed a decrease in pressure in the rectum on the 10th day after the injection of A-type botulinum toxin into the segment of the descending colon. The indices of the intestinal wall tension did not differ before the administration of A-type botulinum toxin, as well as in 10 and 20 minutes. The tension in the administration area of A-type botulinum toxin decreased by 81% on the 10th day after injection. There was an indirect decrease in smooth muscle tone in the segments of the colon above and below the injection by 49 and 80%, respectively. Conclusion. The decrease in rectal pressure on the 10th day after the administration of A-type botulinum toxin directly depends upon the decrease in the biovoltage of the overlying sections. Further basic research is needed to assess the effect of the toxin on non-targeted smooth muscle." @default.
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- W4207076316 date "2022-01-20" @default.
- W4207076316 modified "2023-09-26" @default.
- W4207076316 title "New data on the effect of A-type botulinum toxin on the colon smooth muscles in the experiment" @default.
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- W4207076316 doi "https://doi.org/10.21508/1027-4065-2021-66-6-88-93" @default.
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