FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4207078212> ?p ?o ?g. }

• W4207078212 abstract "The addition of consolidation chemotherapy to preoperative short-course radiotherapy during the prolonged interval between the completion of radiation and surgery in locally advanced rectal cancer (LARC) could enhance pathologic response and might act on potential micrometastasis. We performed this meta-analysis to evaluate whether short-course radiotherapy followed by consolidation chemotherapy (SCRT/CCT) could be a neoadjuvant treatment option compared with conventional long-course chemoradiotherapy (LCCRT).We searched the PubMed, EMBASE, MEDLINE, and Cochrane Library databases. The primary endpoints were pathological outcomes, and the secondary endpoints included survival rate, sphincter preservation rate, R0 resection rate and toxicity. RevMan 5.3 was used to calculate pooled risk ratio (RRs) and 95% confidence intervals (CIs).A total of seven eligible studies and 1865 participants were included in this meta-analysis. Compared with the LCCRT, SCRT/CCT increased pathologic complete response (pCR) rate [RR = 1.74, 95% CI (1.41, 2.15), P < 0.01] and led to a lower proportion of patients with adjuvant pathologic tumor stage 3-4 (ypT3-4) disease [RR = 0.88, 95% CI (0.80, 0.97), P = 0.01] or lymph node positive (ypN +) disease [RR = 0.83, 95% CI (0.71, 0.98), P = 0.02]. In addition, the disease-free survival (DFS) was better in SCRT/CCT group [RR = 1.10, 95% CI (1.02, 1.18), P = 0.01], while overall survival rate and toxicity and surgical procedures were similar between two groups.Based on better pathological outcomes and DFS in SCRT/CCT group, we recommended preoperative short-course radiotherapy followed by consolidation chemotherapy as the optional neoadjuvant treatment for LARC." @default.
• W4207078212 created "2022-01-26" @default.
• W4207078212 creator A5026049732 @default.
• W4207078212 creator A5030362253 @default.
• W4207078212 creator A5047711735 @default.
• W4207078212 creator A5058417243 @default.
• W4207078212 creator A5072907589 @default.
• W4207078212 creator A5075757558 @default.
• W4207078212 date "2022-01-24" @default.
• W4207078212 modified "2023-09-25" @default.
• W4207078212 title "Preoperative short-course radiotherapy followed by consolidation chemotherapy for treatment with locally advanced rectal cancer: a meta-analysis" @default.
• W4207078212 cites W1896630734 @default.
• W4207078212 cites W1928621270 @default.
• W4207078212 cites W2005023050 @default.
• W4207078212 cites W2057901226 @default.
• W4207078212 cites W2073631512 @default.
• W4207078212 cites W2075459753 @default.
• W4207078212 cites W2082778323 @default.
• W4207078212 cites W2095439981 @default.
• W4207078212 cites W2100241851 @default.
• W4207078212 cites W2102886345 @default.
• W4207078212 cites W2110154965 @default.
• W4207078212 cites W2115153468 @default.
• W4207078212 cites W2116475791 @default.
• W4207078212 cites W2122262640 @default.
• W4207078212 cites W2123669280 @default.
• W4207078212 cites W2124886112 @default.
• W4207078212 cites W2128614191 @default.
• W4207078212 cites W2138728054 @default.
• W4207078212 cites W2144717403 @default.
• W4207078212 cites W2149711218 @default.
• W4207078212 cites W2159511785 @default.
• W4207078212 cites W2461601401 @default.
• W4207078212 cites W2519119230 @default.
• W4207078212 cites W2586403573 @default.
• W4207078212 cites W2601892547 @default.
• W4207078212 cites W2623754168 @default.
• W4207078212 cites W2809278331 @default.
• W4207078212 cites W2891131325 @default.
• W4207078212 cites W2925803502 @default.
• W4207078212 cites W2949733640 @default.
• W4207078212 cites W2964024794 @default.
• W4207078212 cites W2967092763 @default.
• W4207078212 cites W3013670950 @default.
• W4207078212 cites W3014994169 @default.
• W4207078212 cites W3033864070 @default.
• W4207078212 cites W3111308000 @default.
• W4207078212 cites W3111609153 @default.
• W4207078212 cites W3112015086 @default.
• W4207078212 cites W3138239215 @default.
• W4207078212 doi "https://doi.org/10.1186/s13014-021-01974-4" @default.
• W4207078212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35073940" @default.
• W4207078212 hasPublicationYear "2022" @default.
• W4207078212 type Work @default.
• W4207078212 citedByCount "1" @default.
• W4207078212 countsByYear W42070782122023 @default.
• W4207078212 crossrefType "journal-article" @default.
• W4207078212 hasAuthorship W4207078212A5026049732 @default.
• W4207078212 hasAuthorship W4207078212A5030362253 @default.
• W4207078212 hasAuthorship W4207078212A5047711735 @default.
• W4207078212 hasAuthorship W4207078212A5058417243 @default.
• W4207078212 hasAuthorship W4207078212A5072907589 @default.
• W4207078212 hasAuthorship W4207078212A5075757558 @default.
• W4207078212 hasBestOaLocation W42070782121 @default.
• W4207078212 hasConcept C126322002 @default.
• W4207078212 hasConcept C141071460 @default.
• W4207078212 hasConcept C143998085 @default.
• W4207078212 hasConcept C2776478404 @default.
• W4207078212 hasConcept C2776694085 @default.
• W4207078212 hasConcept C2778424827 @default.
• W4207078212 hasConcept C44249647 @default.
• W4207078212 hasConcept C509974204 @default.
• W4207078212 hasConcept C71924100 @default.
• W4207078212 hasConcept C82789193 @default.
• W4207078212 hasConcept C95190672 @default.
• W4207078212 hasConceptScore W4207078212C126322002 @default.
• W4207078212 hasConceptScore W4207078212C141071460 @default.
• W4207078212 hasConceptScore W4207078212C143998085 @default.
• W4207078212 hasConceptScore W4207078212C2776478404 @default.
• W4207078212 hasConceptScore W4207078212C2776694085 @default.
• W4207078212 hasConceptScore W4207078212C2778424827 @default.
• W4207078212 hasConceptScore W4207078212C44249647 @default.
• W4207078212 hasConceptScore W4207078212C509974204 @default.
• W4207078212 hasConceptScore W4207078212C71924100 @default.
• W4207078212 hasConceptScore W4207078212C82789193 @default.
• W4207078212 hasConceptScore W4207078212C95190672 @default.
• W4207078212 hasIssue "1" @default.
• W4207078212 hasLocation W42070782121 @default.
• W4207078212 hasLocation W42070782122 @default.
• W4207078212 hasLocation W42070782123 @default.
• W4207078212 hasLocation W42070782124 @default.
• W4207078212 hasLocation W42070782125 @default.
• W4207078212 hasOpenAccess W4207078212 @default.
• W4207078212 hasPrimaryLocation W42070782121 @default.
• W4207078212 hasRelatedWork W1885119863 @default.
• W4207078212 hasRelatedWork W2014943083 @default.
• W4207078212 hasRelatedWork W2217553306 @default.
• W4207078212 hasRelatedWork W2404042595 @default.
• W4207078212 hasRelatedWork W2592774827 @default.
• W4207078212 hasRelatedWork W2626084264 @default.

• next