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- W4207084828 endingPage "102543" @default.
- W4207084828 startingPage "102543" @default.
- W4207084828 abstract "Two-pore channels are ancient members of the voltage-gated ion channel superfamily that are expressed predominantly on acidic organelles such as endosomes and lysosomes. Here we review recent advances in understanding how TPCs are activated by their ligands and identify five salient features: (1) TPCs are Ca2+-permeable non-selective cation channels gated by NAADP. (2) NAADP activation is indirect through associated NAADP receptors. (3) TPCs are also Na+-selective channels gated by PI(3,5)P2. (4) PI(3,5)P2 activation is direct through a structurally-resolved binding site. (5) TPCs switch their ion selectivity in an agonist-dependent manner." @default.
- W4207084828 created "2022-01-26" @default.
- W4207084828 creator A5047521750 @default.
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- W4207084828 creator A5065029982 @default.
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- W4207084828 creator A5072477935 @default.
- W4207084828 date "2022-05-01" @default.
- W4207084828 modified "2023-09-25" @default.
- W4207084828 title "Activation of endo-lysosomal two-pore channels by NAADP and PI(3,5)P2. Five things to know." @default.
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- W4207084828 doi "https://doi.org/10.1016/j.ceca.2022.102543" @default.
- W4207084828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35123238" @default.
- W4207084828 hasPublicationYear "2022" @default.
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