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- W420751203 abstract "The article by Chi et al. in this issue shows that the changes of the electroencephalogram (EEG) produced by a slow infusion of sufentanil for induction of reached a plateau after 2 -4 i.tg. kgt. Continued administration of sufentanil to a total of 10 Ixg kg -~ produced minimal subsequent changes. Loss of consciousness, defined as loss of responsiveness to verbal commands, appeared to coincide with or shortly precede maximal EEG changes. The timing between loss of consciousness and maximal EEG changes was not studied in detail. The authors conclude that the EEG may be used to grade the of anaesthesia during induction until consciousness is lost. What can we learn from this study about the usefulness of the EEG in measuring of anaesthesia? Depth of anaesthesia is not a unitary concept t and is difficult to define. 2 There are three dominant themes in the literature. Articles which deal with the of depth of anaesthesia may: 1 demonstrate a relationship between a measurement and the dose or concentration of the anaesthetic agent. An example is the work of Guedel, 3 who showed that diethyl ether produced a sequence of dose-dependent somatic and autonomic changes, which helped to identify different clinical levels of anaesthesia. Other examples are studies which evaluated changes of the EEG or of sensory-evoked potentials produced by a single anaesthetic agent; 2 2 show a relationship between a measurement and the level of consciousness. 4 The problem of unintentional intraoperative awareness or consciousness ~ is the main source of interest in this question. Studies exploring the possibility of sensory perception and memory in unconscious, adequately anaesthetized 6 patients may be included as a sub-group in this category; 3 show a relationship between a measurement and the adequacy of (usually lack of a somatic or of an adverse haemodynamic response to surgical stimulation). 7 This is a most difficult task. Haemodynamic response to and surgery is influenced by the direct effects of the anaesthetic agent on: (I) the cardiovascular system (i.e., decreased myocardial con-" @default.
- W420751203 created "2016-06-24" @default.
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- W420751203 date "1991-04-01" @default.
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- W420751203 title "Depth of anaesthesia" @default.
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- W420751203 doi "https://doi.org/10.1007/bf03007613" @default.
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