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- W4210252125 abstract "Although numerous prevention and intervention techniques have been developed to counteract catheter-associated urinary tract infections (CAUTIs), urinary catheters remain one of the most common sources of hospital-acquired infections. Nitric oxide (NO), a gaseous free radical responsible for regulating many physiological functions in the body, has gained immense popularity due to its potent, broad-spectrum antimicrobial activity, which is capable of combating medical device-associated infections. In this work, a straightforward solvent-swelling method was used to load the NO donor S-nitroso-N-acetyl-penicillamine (SNAP) into commercial latex catheters (SNAP-UCs) for the first time. The effects of swelling catheters with different concentrations of SNAP solutions (25–125 mg/mL SNAP in tetrahydrofuran (THF)) were studied by measuring the NO release kinetics, SNAP loading, and SNAP leaching. SNAP-UCs impregnated with a 50 mg/mL SNAP-THF solution were found to maximize the amount of SNAP loaded into the latex (0.115 ± 0.009 mg SNAP/mg catheter) and showed physiological levels of NO release (>2 × 10–10 mol min–1 cm–2) over 7 days and minimal SNAP leaching (<2%). SNAP-UCs showed impressive in vitro contact-based and diffusible antimicrobial efficacy against three CAUTI-associated pathogens, reducing the viability of adhered and planktonic Escherichia coli, Proteus mirabilis, and Staphylococcus aureus by ∼98.0 to 99.1% (adhered) and 86.3–96.3% (planktonic) compared to control latex catheters. In vitro cytotoxicity against 3T3 mouse fibroblasts using a CCK-8 assay showed that SNAP-UCs were noncytotoxic (>90% viability). In summary, SNAP-UCs show stable, noncytotoxic NO release characteristics capable of potent, broad-spectrum antimicrobial activity, demonstrating great potential for reducing the devastating effects associated with CAUTIs." @default.
- W4210252125 created "2022-02-08" @default.
- W4210252125 creator A5010565408 @default.
- W4210252125 creator A5024724191 @default.
- W4210252125 creator A5038299435 @default.
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- W4210252125 date "2022-02-04" @default.
- W4210252125 modified "2023-10-10" @default.
- W4210252125 title "Potent, Broad-Spectrum Antimicrobial Effects of <i>S-</i>Nitroso-<i>N</i>-acetylpenicillamine-Impregnated Nitric Oxide-Releasing Latex Urinary Catheters" @default.
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- W4210252125 doi "https://doi.org/10.1021/acsabm.1c01130" @default.
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- W4210252125 hasPublicationYear "2022" @default.
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