Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210255593> ?p ?o ?g. }
- W4210255593 endingPage "471.e3" @default.
- W4210255593 startingPage "460" @default.
- W4210255593 abstract "High-definition vision in humans and nonhuman primates is initiated by cone photoreceptors located within a specialized region of the retina called the fovea. Foveal cone death is the ultimate cause of central blindness in numerous retinal dystrophies, including macular degenerative diseases. 3D retinal organoids (ROs) derived from human pluripotent stem cells (hPSCs) hold tremendous promise to model and treat such diseases. To achieve this goal, RO cones should elicit robust and intrinsic light-evoked electrical responses (i.e., phototransduction) akin to adult foveal cones, which has not yet been demonstrated. Here, we show strong, graded, repetitive, and wavelength-specific light-evoked responses from RO cones. The photoresponses and membrane physiology of a significant fraction of these lab-generated cones are comparable with those of intact ex vivo primate fovea. These results greatly increase confidence in ROs as potential sources of functional human cones for cell replacement therapies, drug testing, and in vitro models of retinal dystrophies." @default.
- W4210255593 created "2022-02-08" @default.
- W4210255593 creator A5041584796 @default.
- W4210255593 creator A5063963894 @default.
- W4210255593 creator A5068671348 @default.
- W4210255593 creator A5085998029 @default.
- W4210255593 creator A5087739263 @default.
- W4210255593 creator A5089958612 @default.
- W4210255593 date "2022-03-01" @default.
- W4210255593 modified "2023-10-16" @default.
- W4210255593 title "Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea" @default.
- W4210255593 cites W1565011663 @default.
- W4210255593 cites W1934543195 @default.
- W4210255593 cites W1967762840 @default.
- W4210255593 cites W1973652650 @default.
- W4210255593 cites W1987644884 @default.
- W4210255593 cites W1994009311 @default.
- W4210255593 cites W1994970646 @default.
- W4210255593 cites W1996609490 @default.
- W4210255593 cites W1998403030 @default.
- W4210255593 cites W1999729097 @default.
- W4210255593 cites W2004697473 @default.
- W4210255593 cites W2006376420 @default.
- W4210255593 cites W2009866472 @default.
- W4210255593 cites W2026840718 @default.
- W4210255593 cites W2027541804 @default.
- W4210255593 cites W2036505824 @default.
- W4210255593 cites W2040831836 @default.
- W4210255593 cites W2045098012 @default.
- W4210255593 cites W2072774299 @default.
- W4210255593 cites W2087344433 @default.
- W4210255593 cites W2116478945 @default.
- W4210255593 cites W2127238314 @default.
- W4210255593 cites W2136159746 @default.
- W4210255593 cites W2142512364 @default.
- W4210255593 cites W2149318439 @default.
- W4210255593 cites W2162367012 @default.
- W4210255593 cites W2164574799 @default.
- W4210255593 cites W2338378167 @default.
- W4210255593 cites W2396697533 @default.
- W4210255593 cites W2405272060 @default.
- W4210255593 cites W2582049971 @default.
- W4210255593 cites W2593955767 @default.
- W4210255593 cites W2604275021 @default.
- W4210255593 cites W2606623351 @default.
- W4210255593 cites W2768530411 @default.
- W4210255593 cites W2795076639 @default.
- W4210255593 cites W28289623 @default.
- W4210255593 cites W2882986564 @default.
- W4210255593 cites W2904334833 @default.
- W4210255593 cites W2913265871 @default.
- W4210255593 cites W2943521526 @default.
- W4210255593 cites W2944813712 @default.
- W4210255593 cites W2976053079 @default.
- W4210255593 cites W3004468317 @default.
- W4210255593 cites W3008881558 @default.
- W4210255593 cites W3033705598 @default.
- W4210255593 cites W3081257112 @default.
- W4210255593 cites W3087102910 @default.
- W4210255593 cites W3087335571 @default.
- W4210255593 cites W3118034245 @default.
- W4210255593 cites W3135263581 @default.
- W4210255593 cites W3210010399 @default.
- W4210255593 cites W4251106870 @default.
- W4210255593 doi "https://doi.org/10.1016/j.stem.2022.01.002" @default.
- W4210255593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35104442" @default.
- W4210255593 hasPublicationYear "2022" @default.
- W4210255593 type Work @default.
- W4210255593 citedByCount "20" @default.
- W4210255593 countsByYear W42102555932022 @default.
- W4210255593 countsByYear W42102555932023 @default.
- W4210255593 crossrefType "journal-article" @default.
- W4210255593 hasAuthorship W4210255593A5041584796 @default.
- W4210255593 hasAuthorship W4210255593A5063963894 @default.
- W4210255593 hasAuthorship W4210255593A5068671348 @default.
- W4210255593 hasAuthorship W4210255593A5085998029 @default.
- W4210255593 hasAuthorship W4210255593A5087739263 @default.
- W4210255593 hasAuthorship W4210255593A5089958612 @default.
- W4210255593 hasBestOaLocation W42102555931 @default.
- W4210255593 hasConcept C104317684 @default.
- W4210255593 hasConcept C105702510 @default.
- W4210255593 hasConcept C107459253 @default.
- W4210255593 hasConcept C131667965 @default.
- W4210255593 hasConcept C145103041 @default.
- W4210255593 hasConcept C169760540 @default.
- W4210255593 hasConcept C2777093970 @default.
- W4210255593 hasConcept C2779736970 @default.
- W4210255593 hasConcept C2780827179 @default.
- W4210255593 hasConcept C2781114197 @default.
- W4210255593 hasConcept C30181142 @default.
- W4210255593 hasConcept C54355233 @default.
- W4210255593 hasConcept C55493867 @default.
- W4210255593 hasConcept C86803240 @default.
- W4210255593 hasConcept C95444343 @default.
- W4210255593 hasConceptScore W4210255593C104317684 @default.
- W4210255593 hasConceptScore W4210255593C105702510 @default.
- W4210255593 hasConceptScore W4210255593C107459253 @default.
- W4210255593 hasConceptScore W4210255593C131667965 @default.