Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210257019> ?p ?o ?g. }
- W4210257019 abstract "Abstract Heat shock protein (HSP) 40 has emerged as a key actor in both innate and adaptive immunity, whereas the role of HLJ1, a molecular chaperone in HSP40 family, in modulating endotoxin–induced sepsis severity is still unclear. Here, we use single-cell RNA sequencing to characterize mouse liver nonparenchymal cell populations under LPS (lipopolysaccharide) stimulation, and show that HLJ1 deletion affected IFN-γ-related gene signatures in distinct immune cell clusters. HLJ1 deficiency also leads to reduced serum levels of IL-12 in LPS-treated mice, contributing to dampened production of IFN-γ in natural killer cells but not CD4 + or CD8 + T cells, and subsequently to improved survival rate. Adoptive transfer of HLJ1-deleted macrophages into LPS-treated mice results in reduced IL-12 and IFN-γ levels and protects the mice from IFN-γ–dependent mortality. In the context of molecular mechanisms, HLJ1 is an LPS-inducible protein in macrophages and converts misfolded IL-12p35 homodimers to monomers, which maintains bioactive IL-12p70 heterodimerization and secretion. This study suggests HLJ1 causes IFN-γ–dependent septic lethality by promoting IL-12 heterodimerization, and targeting HLJ1 has therapeutic potential in inflammatory diseases involving activating IL-12/IFN-γ axis." @default.
- W4210257019 created "2022-02-08" @default.
- W4210257019 creator A5006702268 @default.
- W4210257019 creator A5006814522 @default.
- W4210257019 creator A5021205903 @default.
- W4210257019 creator A5030548682 @default.
- W4210257019 creator A5040840786 @default.
- W4210257019 creator A5054716842 @default.
- W4210257019 creator A5059484251 @default.
- W4210257019 creator A5063989861 @default.
- W4210257019 creator A5068987378 @default.
- W4210257019 creator A5091640201 @default.
- W4210257019 date "2022-01-06" @default.
- W4210257019 modified "2023-09-27" @default.
- W4210257019 title "HLJ1 amplifies endotoxin–induced sepsis severity by promoting IL-12 heterodimerization in macrophages" @default.
- W4210257019 cites W1488772574 @default.
- W4210257019 cites W1550722396 @default.
- W4210257019 cites W1933265869 @default.
- W4210257019 cites W1972966429 @default.
- W4210257019 cites W1986342126 @default.
- W4210257019 cites W1992075095 @default.
- W4210257019 cites W1996590291 @default.
- W4210257019 cites W1998156781 @default.
- W4210257019 cites W2001722118 @default.
- W4210257019 cites W2022530914 @default.
- W4210257019 cites W2029396930 @default.
- W4210257019 cites W2052429062 @default.
- W4210257019 cites W2058258787 @default.
- W4210257019 cites W2060179307 @default.
- W4210257019 cites W2060222319 @default.
- W4210257019 cites W2065278356 @default.
- W4210257019 cites W2068818475 @default.
- W4210257019 cites W2072872180 @default.
- W4210257019 cites W2075056405 @default.
- W4210257019 cites W2081361232 @default.
- W4210257019 cites W2083513831 @default.
- W4210257019 cites W2088167857 @default.
- W4210257019 cites W2093199673 @default.
- W4210257019 cites W2096168817 @default.
- W4210257019 cites W2101385118 @default.
- W4210257019 cites W2101411328 @default.
- W4210257019 cites W2103289907 @default.
- W4210257019 cites W2117470117 @default.
- W4210257019 cites W2123073309 @default.
- W4210257019 cites W2136862034 @default.
- W4210257019 cites W2151608099 @default.
- W4210257019 cites W2164990391 @default.
- W4210257019 cites W2166190627 @default.
- W4210257019 cites W2268066121 @default.
- W4210257019 cites W2280404143 @default.
- W4210257019 cites W2507511859 @default.
- W4210257019 cites W2526524223 @default.
- W4210257019 cites W2580937739 @default.
- W4210257019 cites W2602036000 @default.
- W4210257019 cites W2617620062 @default.
- W4210257019 cites W2750243369 @default.
- W4210257019 cites W2789737735 @default.
- W4210257019 cites W2792420975 @default.
- W4210257019 cites W2907359354 @default.
- W4210257019 cites W2914567327 @default.
- W4210257019 cites W2949177718 @default.
- W4210257019 cites W2954926994 @default.
- W4210257019 cites W2968872536 @default.
- W4210257019 cites W2972899524 @default.
- W4210257019 cites W3001118548 @default.
- W4210257019 cites W3001317991 @default.
- W4210257019 cites W3002108456 @default.
- W4210257019 cites W3008450806 @default.
- W4210257019 cites W3009300613 @default.
- W4210257019 cites W3009885589 @default.
- W4210257019 cites W3011568661 @default.
- W4210257019 cites W3012353111 @default.
- W4210257019 cites W3037676127 @default.
- W4210257019 cites W3112902030 @default.
- W4210257019 cites W3165656738 @default.
- W4210257019 cites W3182774911 @default.
- W4210257019 cites W4236927961 @default.
- W4210257019 doi "https://doi.org/10.1101/2022.01.05.475083" @default.
- W4210257019 hasPublicationYear "2022" @default.
- W4210257019 type Work @default.
- W4210257019 citedByCount "0" @default.
- W4210257019 crossrefType "posted-content" @default.
- W4210257019 hasAuthorship W4210257019A5006702268 @default.
- W4210257019 hasAuthorship W4210257019A5006814522 @default.
- W4210257019 hasAuthorship W4210257019A5021205903 @default.
- W4210257019 hasAuthorship W4210257019A5030548682 @default.
- W4210257019 hasAuthorship W4210257019A5040840786 @default.
- W4210257019 hasAuthorship W4210257019A5054716842 @default.
- W4210257019 hasAuthorship W4210257019A5059484251 @default.
- W4210257019 hasAuthorship W4210257019A5063989861 @default.
- W4210257019 hasAuthorship W4210257019A5068987378 @default.
- W4210257019 hasAuthorship W4210257019A5091640201 @default.
- W4210257019 hasBestOaLocation W42102570191 @default.
- W4210257019 hasConcept C104317684 @default.
- W4210257019 hasConcept C136449434 @default.
- W4210257019 hasConcept C151730666 @default.
- W4210257019 hasConcept C164027704 @default.
- W4210257019 hasConcept C167672396 @default.
- W4210257019 hasConcept C203014093 @default.
- W4210257019 hasConcept C205260736 @default.