Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210257364> ?p ?o ?g. }
- W4210257364 endingPage "1478" @default.
- W4210257364 startingPage "1467" @default.
- W4210257364 abstract "B-cells are antibody-producing cells of the adaptive immune system. Approximately 75% of all newly generated B-cells in the bone marrow are autoreactive and express potentially harmful autoantibodies. To prevent autoimmune disease, the immune system has evolved a powerful mechanism to eliminate autoreactive B-cells, termed negative B-cell selection. While designed to remove autoreactive clones during early B-cell development, our laboratory recently discovered that transformed B-cells in leukemia and lymphoma are also subject to negative selection. Indeed, besides the risk of developing autoimmune disease, B-cells are inherently prone to malignant transformation: to produce high-affinity antibodies, B-cells undergo multiple rounds of somatic immunoglobulin gene recombination and hypermutation. Reflecting high frequencies of DNA-breaks, adaptive immune protection by B-cells comes with a dramatically increased risk of development of leukemia and lymphoma. Of note, B-cells exist under conditions of chronic restriction of energy metabolism. Here we discuss how these metabolic gatekeeper functions during B-cell development provide a common mechanism for the removal of autoreactive and premalignant B-cells to safeguard against both autoimmune diseases and B-cell malignancies." @default.
- W4210257364 created "2022-02-08" @default.
- W4210257364 creator A5018763923 @default.
- W4210257364 creator A5047777785 @default.
- W4210257364 creator A5057040530 @default.
- W4210257364 creator A5083834729 @default.
- W4210257364 date "2021-06-30" @default.
- W4210257364 modified "2023-09-27" @default.
- W4210257364 title "Metabolic determinants of B-cell selection" @default.
- W4210257364 cites W126560450 @default.
- W4210257364 cites W1533868833 @default.
- W4210257364 cites W1599349966 @default.
- W4210257364 cites W1649547160 @default.
- W4210257364 cites W1847661316 @default.
- W4210257364 cites W1916983144 @default.
- W4210257364 cites W1926727282 @default.
- W4210257364 cites W1967407054 @default.
- W4210257364 cites W1969140398 @default.
- W4210257364 cites W1970027248 @default.
- W4210257364 cites W1971347970 @default.
- W4210257364 cites W1972272040 @default.
- W4210257364 cites W1979816280 @default.
- W4210257364 cites W1989279522 @default.
- W4210257364 cites W1992372128 @default.
- W4210257364 cites W1994025158 @default.
- W4210257364 cites W1996022168 @default.
- W4210257364 cites W2004081720 @default.
- W4210257364 cites W2004170579 @default.
- W4210257364 cites W2005555847 @default.
- W4210257364 cites W2007886976 @default.
- W4210257364 cites W2011444435 @default.
- W4210257364 cites W2015345028 @default.
- W4210257364 cites W2017035524 @default.
- W4210257364 cites W2018306897 @default.
- W4210257364 cites W2019383774 @default.
- W4210257364 cites W2019683289 @default.
- W4210257364 cites W2023947368 @default.
- W4210257364 cites W2024996887 @default.
- W4210257364 cites W2028897202 @default.
- W4210257364 cites W2031263707 @default.
- W4210257364 cites W2032848771 @default.
- W4210257364 cites W2033316505 @default.
- W4210257364 cites W2033790900 @default.
- W4210257364 cites W2037768649 @default.
- W4210257364 cites W2040329520 @default.
- W4210257364 cites W2044512941 @default.
- W4210257364 cites W2045378618 @default.
- W4210257364 cites W2050651394 @default.
- W4210257364 cites W2061229403 @default.
- W4210257364 cites W2063662864 @default.
- W4210257364 cites W2065993573 @default.
- W4210257364 cites W2068412287 @default.
- W4210257364 cites W2074677800 @default.
- W4210257364 cites W2074798171 @default.
- W4210257364 cites W2076198413 @default.
- W4210257364 cites W2079580613 @default.
- W4210257364 cites W2084299345 @default.
- W4210257364 cites W2086800018 @default.
- W4210257364 cites W2089487151 @default.
- W4210257364 cites W2090512438 @default.
- W4210257364 cites W2091141292 @default.
- W4210257364 cites W2091664866 @default.
- W4210257364 cites W2092115508 @default.
- W4210257364 cites W2095405591 @default.
- W4210257364 cites W2095547255 @default.
- W4210257364 cites W2095764447 @default.
- W4210257364 cites W2102140136 @default.
- W4210257364 cites W2106223802 @default.
- W4210257364 cites W2107958082 @default.
- W4210257364 cites W2111321718 @default.
- W4210257364 cites W2112912738 @default.
- W4210257364 cites W2116758852 @default.
- W4210257364 cites W2118028844 @default.
- W4210257364 cites W2118128813 @default.
- W4210257364 cites W2119967034 @default.
- W4210257364 cites W2121510983 @default.
- W4210257364 cites W2126766896 @default.
- W4210257364 cites W2127769439 @default.
- W4210257364 cites W2129141528 @default.
- W4210257364 cites W2139739952 @default.
- W4210257364 cites W2139987952 @default.
- W4210257364 cites W2149589020 @default.
- W4210257364 cites W2158313095 @default.
- W4210257364 cites W2159332511 @default.
- W4210257364 cites W2165451672 @default.
- W4210257364 cites W2166600785 @default.
- W4210257364 cites W2167692982 @default.
- W4210257364 cites W2178468712 @default.
- W4210257364 cites W2277318350 @default.
- W4210257364 cites W2300592511 @default.
- W4210257364 cites W2345102372 @default.
- W4210257364 cites W2473268164 @default.
- W4210257364 cites W2554580516 @default.
- W4210257364 cites W2560542232 @default.
- W4210257364 cites W2561714923 @default.
- W4210257364 cites W2562213801 @default.
- W4210257364 cites W2563700816 @default.
- W4210257364 cites W2587039580 @default.