FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210261736> ?p ?o ?g. }

• W4210261736 endingPage "2407" @default.
• W4210261736 startingPage "2399" @default.
• W4210261736 abstract "The potential toxicity of nanoparticles, especially for clinically applicable ones, has become a critical concern. Technologies that can in situ-evaluate the toxicity of nanoparticles with high sensitivity are urgently needed. In this study, a facile strategy was developed for sensitive detection on the nanotoxicity of nanoparticles with low toxicity or a low dose. A functional nanoprobe loaded with molecular beacons was constructed to realize in situ evaluation of the nanotoxicity through probing multiple miRNAs in nanoparticle-exposed living cells. Being composed of protamine complexed with molecular beacons for miRNA detection and decorated by TAT and KALA peptides, the dual-peptide functionalized nanoprobe can efficiently deliver molecular beacons into living cells to realize the real-time monitoring of early biomarkers (miR-21 and miR-221) to evaluate nanotoxicity. Using mesoporous silica nanoparticles (MSNs) with different surface modifications as typical representatives of low toxic nanoparticles, we demonstrate that our nanoprobe can sensitively detect miRNA changes in cells under diverse exposure conditions, that is, MSN-NH2 exhibits the strongest capability to upregulate miR-21 and miR-221, and the upregulation is exposure dose- and time-dependent. Our approach is much more sensitive as compared with conventional methods to study cytotoxicity such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, cell morphology observation, and reactive oxygen species (ROS) assay. This study paves a path for effective and facile nanotoxicity evaluation and provides insights into the biological impacts of MSNs." @default.
• W4210261736 created "2022-02-08" @default.
• W4210261736 creator A5021775481 @default.
• W4210261736 creator A5027335938 @default.
• W4210261736 creator A5035121335 @default.
• W4210261736 creator A5038418695 @default.
• W4210261736 creator A5038811887 @default.
• W4210261736 creator A5046248892 @default.
• W4210261736 creator A5048379858 @default.
• W4210261736 creator A5084688862 @default.
• W4210261736 date "2022-01-31" @default.
• W4210261736 modified "2023-10-14" @default.
• W4210261736 title "In Situ Detection of Nanotoxicity in Living Cells Based on Multiple miRNAs Probed by a Peptide Functionalized Nanoprobe" @default.
• W4210261736 cites W1973558093 @default.
• W4210261736 cites W1985769494 @default.
• W4210261736 cites W1995961820 @default.
• W4210261736 cites W2002995168 @default.
• W4210261736 cites W2017751726 @default.
• W4210261736 cites W2022544679 @default.
• W4210261736 cites W2035765569 @default.
• W4210261736 cites W2061558045 @default.
• W4210261736 cites W2087812848 @default.
• W4210261736 cites W2096367638 @default.
• W4210261736 cites W2099942267 @default.
• W4210261736 cites W2117981139 @default.
• W4210261736 cites W2124158735 @default.
• W4210261736 cites W2127013573 @default.
• W4210261736 cites W2128153968 @default.
• W4210261736 cites W2156406953 @default.
• W4210261736 cites W2503971382 @default.
• W4210261736 cites W2588025094 @default.
• W4210261736 cites W2741728864 @default.
• W4210261736 cites W2745898725 @default.
• W4210261736 cites W2766042821 @default.
• W4210261736 cites W2768664509 @default.
• W4210261736 cites W2790257120 @default.
• W4210261736 cites W2797152560 @default.
• W4210261736 cites W2801405338 @default.
• W4210261736 cites W2805529674 @default.
• W4210261736 cites W2896471204 @default.
• W4210261736 cites W2913989033 @default.
• W4210261736 cites W2915415778 @default.
• W4210261736 cites W2915473767 @default.
• W4210261736 cites W2940875564 @default.
• W4210261736 cites W2990888454 @default.
• W4210261736 cites W2996020953 @default.
• W4210261736 cites W3005834159 @default.
• W4210261736 cites W3033349633 @default.
• W4210261736 cites W3084685188 @default.
• W4210261736 cites W3088002445 @default.
• W4210261736 cites W3098925819 @default.
• W4210261736 cites W3109707794 @default.
• W4210261736 cites W3121030156 @default.
• W4210261736 cites W3154979570 @default.
• W4210261736 cites W3169533010 @default.
• W4210261736 cites W3083478401 @default.
• W4210261736 doi "https://doi.org/10.1021/acs.analchem.1c03950" @default.
• W4210261736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35099175" @default.
• W4210261736 hasPublicationYear "2022" @default.
• W4210261736 type Work @default.
• W4210261736 citedByCount "4" @default.
• W4210261736 countsByYear W42102617362022 @default.
• W4210261736 crossrefType "journal-article" @default.
• W4210261736 hasAuthorship W4210261736A5021775481 @default.
• W4210261736 hasAuthorship W4210261736A5027335938 @default.
• W4210261736 hasAuthorship W4210261736A5035121335 @default.
• W4210261736 hasAuthorship W4210261736A5038418695 @default.
• W4210261736 hasAuthorship W4210261736A5038811887 @default.
• W4210261736 hasAuthorship W4210261736A5046248892 @default.
• W4210261736 hasAuthorship W4210261736A5048379858 @default.
• W4210261736 hasAuthorship W4210261736A5084688862 @default.
• W4210261736 hasConcept C109316439 @default.
• W4210261736 hasConcept C119203544 @default.
• W4210261736 hasConcept C12554922 @default.
• W4210261736 hasConcept C127445965 @default.
• W4210261736 hasConcept C129312508 @default.
• W4210261736 hasConcept C155672457 @default.
• W4210261736 hasConcept C16387964 @default.
• W4210261736 hasConcept C171250308 @default.
• W4210261736 hasConcept C178790620 @default.
• W4210261736 hasConcept C185592680 @default.
• W4210261736 hasConcept C192562407 @default.
• W4210261736 hasConcept C202751555 @default.
• W4210261736 hasConcept C2777822432 @default.
• W4210261736 hasConcept C552990157 @default.
• W4210261736 hasConcept C55493867 @default.
• W4210261736 hasConcept C86803240 @default.
• W4210261736 hasConceptScore W4210261736C109316439 @default.
• W4210261736 hasConceptScore W4210261736C119203544 @default.
• W4210261736 hasConceptScore W4210261736C12554922 @default.
• W4210261736 hasConceptScore W4210261736C127445965 @default.
• W4210261736 hasConceptScore W4210261736C129312508 @default.
• W4210261736 hasConceptScore W4210261736C155672457 @default.
• W4210261736 hasConceptScore W4210261736C16387964 @default.
• W4210261736 hasConceptScore W4210261736C171250308 @default.
• W4210261736 hasConceptScore W4210261736C178790620 @default.
• W4210261736 hasConceptScore W4210261736C185592680 @default.
• W4210261736 hasConceptScore W4210261736C192562407 @default.

• next